婴儿湿疹与家族过敏史及血清总IgE的相关性研究  

Association of Infant Eczema with Family History of Allergy and Serum Total IgE

作　　者：毛晓晖 张德光 MAO Xiao-hui;ZHANG De-guang(The Maternity and Child Health Care Hospital of Zhifu District,Yantai,Shandong,264001)

机构地区：[1]山东烟台市芝罘区妇幼保健院,山东烟台264001

出　　处：《智慧健康》2018年第20期43-46,49,共5页Smart Healthcare

摘　　要：目的分析脐血总Ig E水平、过敏性疾病家族史与婴儿湿疹之间的关系,探讨婴儿湿疹发病相关因素,为临床早期预防和干预婴儿湿疹提供思路。方法选取2011年12月至2012年12月在本院足月出生的新生儿241例。抽取脐静脉血2~3m L,离心后取血清,-20℃保存备用。应用酶联免疫(ELSIA)检测法测定脐血总Ig E。建立湿疹问卷(编号同脐血),询问父母及其他家族成员过敏性疾病史情况,随后于婴儿满1个月、3个月、6个月共随访3次。与脐血总Ig E结合,对有无家族过敏史与婴儿湿疹发病率进行卡方检验差异性统计分析;对脐血总Ig E不同水平与婴儿湿疹发病率进行卡方检验差异性统计分析;对有、无家族过敏史两组婴儿脐血Ig E水平进行秩相关差异性统计分析;对湿疹婴儿与无湿疹婴儿脐血总Ig E水平进行秩相关差异性统计分析。结果 (1)有家族过敏史者与无家族史婴儿发病率比较,χ2=9.6,P<0.05。家族过敏史与湿疹发病密切相关。(2)对脐血总Ig E不同水平,经多个独立样本卡方检验统计分析,χ2=1.14,P>0.05,湿疹发病与总Ig E无关,无统计学意义。(3)家族过敏史与无家族过敏史的婴儿脐血总Ig E,经独立样本秩相关统计分析,t1=7801.5,t2=21359.5,Z=-1.694,P=0.09,差异性无统计学意义。(4)湿疹婴儿脐血总Ig E与无湿疹婴儿脐血Ig E,经独立样本秩相关统计分析,t1=9493.5,t2=19667.5,Z=-0.602,P=0.547,差异性无统计学意义。结论 (1)有家族过敏性史婴儿湿疹发病率高,提示家族过敏史是湿疹发病的高危因素。(2)有、无家族过敏史婴儿脐血总Ig E比较无相关性,提示家族过敏史与脐血总Ig E不相关。(3)湿疹婴儿与无湿疹婴儿脐血总Ig E比较无相关性。(4)脐血总Ig E不同水平水平与湿疹发病率无差异性,提示婴儿湿疹发病与脐血总Ig E不相关,单纯检测脐血Ig E水平不能预测婴儿湿疹的发病风险。Objective To find out high risk factors of infantile eczema; and searches the methods of early preventing and intervening infantile eczema and other allergic diseases. Methods 241 neonates born in our hospital from December 2011 to December 2012 were selected. 2~3 m L was extracted from umbilical vein blood and serum was centrifuged and stored at-20 C. The total Ig E in cord blood was determined by enzyme linked immunosorbent assay（ELSIA）. An eczema questionnaire（numbered with umbilical cord blood） was established to inquire about the history of allergic diseases among parents and other family members, followed by a total of 3 times in the 1, 3, and 6 months of the baby. Combined with umbilical cord blood total Ig E, chi square test was used to analyze the incidence of allergic history and the incidence of infantile eczema; The difference of the total Ig E levels of umbilical cord blood and the incidence of infantile eczema was analyzed by chi square test; The Ig E levels of cord blood in two groups of infants with or without family history of allergy were analyzed by rank correlation difference; Statistical analysis was performed on rank Ig E difference between umbilical cord blood and eczema infants. Result（1） According to independent sample chi-square test, the incidence of eczema with and without history of allergic diseases is χ2=9.6,P〈0.05. The difference is statistically significant.（2）According to independent sample chi-square test of different cord blood＇s total Ig E levels, χ2=1.14,P〉0.05, the difference is not statistically significant.（3）By the rank correlation analysis, cord blood＇s total Ig E of infants with and without family history of allergic diseases is t1=7801.5, t2=21359.5, Z=-1.694, P=0.09.The difference is not statistically significant.（4）According to independent sample rank test, cord blood＇s total Ig E of infants with and without eczema is t1=9493.5, t2=19667.5, Z=-0.602, P=0.547. The difference is not statistically significant. Conclusion（1）The inc

关 键 词：脐血 总IGE 婴儿湿疹 家族过敏性疾病史 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]