免疫球蛋白检验对乙型肝炎患者的临床效果观察  

Clinical effect observation of immunoglobulin test in patients with hepatitis B

作　　者：史琼英[1] 陈春华[1] 何梅芳 SHI Qiong-ying;CHEN Chun-hua(Department of Clinical Laboratory,Changzhou Third People＇s Hospital of Jiangsu Province,Changzhou 213001,China)

机构地区：[1]江苏省常州市第三人民医院检验科,213001 [2]不详

出　　处：《中国实用医药》2018年第26期17-19,共3页China Practical Medicine

摘　　要：目的探讨免疫球蛋白检验在乙型肝炎患者疾病诊断中的价值。方法 100例乙型肝炎患者,根据病情严重程度分为实验组A(重型乙型肝炎)和实验组B(慢性乙型肝炎),各50例。另选取同期50例健康体检者为对照组。并根据患者的症状改善情况分为改善组(54例)和非改善组(46例)。比较三组受检者免疫球蛋白M(IgM)、免疫球蛋白A(IgA)、免疫球蛋白G(IgG)水平,同时比较改善组和非改善组患者IgM、IgA、IgG、凝血酶原活动度(PTA)和总胆红素(TBIL)水平。结果实验组A患者IgM、IgA、IgG水平均明显高于实验组B和对照组,差异有统计学意义(P<0.05);实验组B患者IgM(2.13±0.36)g/L、IgA(2.31±0.66)g/L、IgG(13.97±2.75)g/L水平明显高于对照组的(1.47±0.16)、(1.71±0.31)、(11.35±2.18)g/L,差异有统计学意义(P<0.05)。改善组患者IgM、IgA、IgG、PTA和TBIL水平明显优于非改善组,差异有统计学意义(P<0.05)。结论乙型肝炎患者接受免疫球蛋白检验,对其疾病的诊断和预后的评估,有着积极的意义,值得应用。Objective To investigate the diagnostic value of immunoglobulin test in patients with hepatitis B. Methods A total of 100 patients with hepatitis B were divided into experimental group A （severe hepatitis B） and experimental group B （chronic hepatitis B） according to the severity of the disease, 50 cases in each group. Another 50 healthy persons in the same period were selected as control group. According to the improvement of symptoms, all patients were divided into the improvement group （54 cases） and the non improvement group （46 cases）. The levels of immunoglobulin M （IgM）, immunoglobulin A （IgA）, immunoglobulin G （IgG） in subjects of three groups were compared. The levels of IgM, IgA, IgG, prothrombin activity （PTA） and total bilimbin （TBIL） were compared between the improvement group and the non improvement group. Results The levels of IgM, IgA and IgG in the experimental group A were significantly higher than those in the experimental group B and the coptrol group, the differences were statistically significant （P〈0.05）. The levels of IgM, IgA and IgG in the experimental group B were （2.13±0.36） g/L, （2.31±0.66） g/L and （13.97±2.75） g/L, which were significantly higher than （1.47±0.16） g/L, （1.71±0.31） g/L and （11.35±2.18） g/L in the control group, the differences were statistically significant （P〈0.05）. The levels of IgM, IgA, IgG, PTA and TBIL in the improvement group were significantly better than those in the non improvement group, the differences were statistically significant （P〈0.05）. Conclusion Immunoglobulin test for patients with hepatitis B has a positive significance in the diagnosis and prognosis evaluation of the disease, and is worthy of application.

关 键 词：免疫球蛋白 乙型肝炎 检验 

分 类 号：R512.62[医药卫生—内科学]