基于回顾性研究的何首乌风险因素分析与安全应用建议  

Risk factors analysis and security application discussion of Polygonum multiflorum based on retrospective study

作　　者：赖潇潇[1] 吴俊标[1] 陈设[1] 赖平 汪小惠[1] 王颖彦[1] 罗懿妮[1] 林华[1] LAI Xiao-xiao;WU Jun-biao;CHEN She;LAI Ping;WANG Xiao-hui;WANG Ying-yan;LUO Yi-ni;LIN Hua(Guangdong Provincal Hospital of Chinese Medicine,Guangzhou 510120,China)

机构地区：[1]广东省中医院

出　　处：《中国中药杂志》2018年第15期3205-3210,共6页China Journal of Chinese Materia Medica

基　　金：广东省中医院中医药科学院技术研究专项(YN2016YX04)

摘　　要：近年来何首乌的肝毒性问题引起了国内外的高度关注,国内学者也针对何首乌的致肝损因素进行了多方面的探索,如中草药相关肝损伤临床诊疗指南的建立和何首乌肝细胞毒性与化学成分、溶剂、炮制、使用及患者病理基础的关系等。笔者通过回顾性分析何首乌相关性肝损伤的个案报道,尝试将最新的理论研究成果结合到实际案例中,从理论到实践再次评估分析何首乌的致肝损伤风险因素及辨识特征,并从何首乌应用个体、药物选用及服用要求等方面提出相关建议,以进一步提高中药何首乌的临床应用安全提供参考。In recent years,hepatotoxicity problem of Polygonum multiflorum has caused high attention. Domestic scholars also explored the causes of liver damage caused by it. For example,the establishment of guideline for diagnosis and treatment of herb-induced liver injury,and the theory about relationship between hepatocyte toxicity and chemical composition,solvents,processing,use and pathological basis of patients and so on. To try to combine theory with practice,author analyzed risk factors about the case reports of P. multiflorum causing liver damage,and made some suggestions on P. multiflorum about individualized application,drug selection and requirements for taking. This for providing reference for the safe use of P. multiflorum.

关 键 词：何首乌 肝损伤 风险因素 应用建议 

分 类 号：R285[医药卫生—中药学]