黄连等6味中草药对耐药性鲍曼不动杆菌的抑菌作用研究  

Study on Bacteriostatic Effect of 6 Kinds of Chinese Herbal Medicines as Coptis Chinensis on Resistant Acinetobacter Baumannii

作　　者：赵娜[1] 农凤鸣 汤丽霞[1] 黄燕[3] 韦莹慧[3] 唐玉莲[1] 黄跃斌[1] ZHAO Na;NONG Fengming;TANG Lixia;HUANG Yan;WEI Yinghui;TANG Yulian;HUANG Yuebin(Inspection and Training Department,Youjiang Medical College for Nationalities,Baise,Guangxi 533000;Institute for Food and Drug Control of Baise,Baise,Guangxi 533000;Department of Clinical Laboratory,Affiliated Hospital of Youjiang Medical College for Nationalities,Baise,Gnangxi 533000)

机构地区：[1]右江民族医学院检验实训部,广西百色533000 [2]百色巿食品药品检验所,广西百色533000 [3]右江民族医学院附属医院检验科,广西百色533000

出　　处：《中国中医药科技》2018年第5期670-671,674,共3页Chinese Journal of Traditional Medical Science and Technology

基　　金：2013年中医药民族医药继承创新工程立项课题(GZZC13-22)

摘　　要：目的:观察黄连等6味中草药对耐药性鲍曼不动杆菌的体外抑菌作用。方法:选用黄连、黄柏、黄芩、白头翁、千里光和金银花6味中草药,采用水煎法和醇提法来提取其有效成分,采用K-B法进行测定上述6味中草药两种提取物对耐药性鲍曼不动杆菌的体外抑菌作用。结果:菌液浓度为1.0 g/L时,6味种草药均有一定的抑菌作用;而菌液浓度在0.5、0.25 g/L时药物的抑菌效果更明显,其中以黄连、黄芩的抑菌作用最为显著。结论:6味中草药均有不同程度的抑菌作用,其中黄连、黄芩水煎法和醇提法提取物对耐药性鲍曼不动杆菌的抑菌作用显著。Objective： Observing the bacteriostatic effect of 6 kinds of Chinese herbal medicines such as Rhizoma Coptidis on the antibiotic resistance Acinetobacter baumannii. Methods：Selecting 6 kinds of herbs,Coptis,Scutellaria,Phellodendron,Pulsatilla,Senecio and Honeysuckle,extracting the effective components of their water and ethanol extraction,the bacteriostatic effect of 6 kinds of Chinese herbal medicines water and ethanol extraction on antibiotic resistance Acinetobacter baumannii was determined by K-B method. Results：In the concentration of bacteria at 1. 0 g/L 6 kinds of medicine showed inhibitory effect at varying degrees and the concentration of bacteria at 0. 5 and 0. 25 g/L,the inhibitory effect was moresignificant,the effect of Coptis,Scutellaria was the most significant. Conclusion： 6 Kinds of Chinese herbal medicines extracts have bacteriostatic effect on antibiotic resistance Acinetobacter baumannii,the effect of Coptis and Scutellaria was the most.

关 键 词：中草药 耐药性 鲍曼不动杆菌 黄连 黄芩 抑菌作用 体外实验 

分 类 号：R285[医药卫生—中药学]