基于同异反分析的寻常型银屑病用药优选  

Optimization of Psoriasis Drugs Based on Same and Similar Back Analysis

作　　者：魏冬慧 吕英[3] 蒯仂 许逊哲 茹意 华亮[1,2] 郑淇 吴人杰[4] 李欣 李斌[1,2] 赵克勤[5] WEI Donghui;LYUYing;KUAI Le;XU Xunzhe;RU Yi;HUA Liang;ZHENG Qi;WU Renjie;LI Xin;LI Bin;ZHAO Keqin(Yueyang Hospital of Integrative Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Dermatology of Shanghai Traditional Chinese Medicine Research Institute,Shanghai 201203,China;The Second Department of Oncology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Institution of Zhuji connection Mathematics,Zhuji 311811,Zhejiang,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海200437 [2]上海市中医药研究院皮肤病研究所,上海201203 [3]上海中医药大学附属岳阳中西医结合医院肿瘤二科,上海200437 [4]上海中医药大学,上海201203 [5]诸暨市联系数学研究所,浙江诸暨311811

出　　处：《中华中医药学刊》2018年第10期2445-2447,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81473682,81704042);国家基础科学人才培养基金项目(J1103607);上海市卫计委项目(ZY3-CCCX-3-3033);上海市科技委员会项目(14401970200);上海中医药大学第十批大学生科创项目(JX61.08.97,JX61.08.98)

摘　　要：目的：在前期研究清热凉血方与益气活血方辨治寻常型银屑病血热证、血瘀证良好临床基础上,采用集对分析的同异反分析两种治法的异同并优选药物。方法：将血热组内服清热凉血方视作集合A;血瘀组内服益气活血方视作集合B。集合A与集合B组成集对H（A,B）,从定性与定量两个角度计算联系数势值比较两种治法的异同,并优选药物。结果：定性角度shiμ（A,B）=0. 75 〈1;定量角度shiμ（A,B）=0. 667 〈1。凉血法和活血法的侧重点难以在系统意义上作趋同看待,优选药物为丹参、菝葜。结论：借助于集对分析的同异反分析,从定性描述及定量计算分析不同治法的同一度及对立度,并得出优选药物。Objective： To study the similarities and differences between the two methods of syndrome differentiation and analysis of the same type of anti-syndromes,And preferably a medicament. Methods： The bloodheat group was treated as a a set of A. The blood stasis group was as the set B. A and B formed the set H. From the qualitative and quantitative calculation,the relationship between the number of potential values of the two similarities and differences in treatmentand the best drugs were compared. Results： The qualitative angle shiμ（ A,B） = 0. 75〈1. Quantitative angle shiμ（A,B） = 0. 667 〈1. Cooling blood and activating blood circulation method of the focus was difficult to make a systematic sense and the best drugs were Salvia and Smilax. Conclusion： By means of the pairwise analysis,the qualitative and quantitative analysis,the different governance law of the same degree and the degree of alignment were studied and derived the preferred drugs.

关 键 词：同异反分析 集对分析 寻常型银屑病 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]