活血潜阳方对尿MA/Cr异常的肥胖相关性高血压病患者的影响  

Effect of Huoxue Qianyang prescription on obesity-related hypertension patients with abnormal urine MA/Cr ratio

作　　者：韩亚楠[1] 符德玉[1] 芦波[1] 周训杰[1] 李建华[1] 徐金美 沈立 桂明泰[1] 姚磊[1] 龙敏[1] 舒婷[1] HAN Ya-nan;FU De-yu;LU Bo;ZHOU Xun-jie;LI Jian-hua;XU Jin-mei;SHEN Li;GUI Ming-tai;YAO Lei;LONG Min;SHU Ting(Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Shanghai Yangpu Hospital of Traditional Chinese Medicine,Shanghai 200090,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,上海200437 [2]上海市杨浦区中医院,上海200090

出　　处：《湖南中医杂志》2018年第9期10-12,共3页Hunan Journal of Traditional Chinese Medicine

基　　金：上海市进一步加快中医药事业发展三年行动计划资助项目(编号:ZY3-CCCX-3-3026);上海市岳阳中西医结合医院高血压重点专病专科资助(2012年)

摘　　要：目的:探讨活血潜阳方对尿微量白蛋白与尿肌酐比值(尿MA/Cr)异常的肥胖相关性高血压病患者的临床疗效。方法:将62例尿MA/Cr异常的原发性高血压病腹型肥胖患者分为治疗组36例(中西医结合疗法)与对照组26例(西医常规疗法),观察3个月后比较2组治疗前后的尿MA/Cr、血压、腹围、中医证候积分的变化。结果:治疗组较对照组尿MA/Cr及中医证候积分均下降,差异均有统计学意义(P<0.05),治疗组治疗前后尿MA/Cr、血压、中医证候积分比较,差异均有统计学意义(P<0.05);而2组腹围比较,差异无统计学意义(P>0.05)。结论:活血潜阳方配合西医常规治疗尿MA/Cr异常的肥胖相关性高血压病疗效优于单纯西药常规治疗,且可明显改善患者血压及中医症状。Objective： To investigate the clinical efficacy of Huoxue Qianyang prescription（ for activating blood circulation and suppressing hyperactive yang） on obesity-related hypertension patients with abnormal urine microalbumin/creatinine（ MA/Cr） ratio. Methods： A total of 62 abdominal obesity-related primary hypertension patients with abnormal urine MA/Cr ratio were divided into treatment group（ 36 cases,treated with integrated traditional Chinese and Western medicine therapy） and control group（ 26 cases,treated with conventional Western medicine therapy）. After three months of observation,the following indices were compared to find the changes between the two groups： urine MA/Cr ratio,blood pressure,abdominal circumference,and traditional Chinese medicine（ TCM） syndrome score. Results： The treatment group showed significant decreases in urine MA/Cr ratio and TCM syndrome score compared with the control group（ P〈0. 05）; in the treatment group,there were significant changes in urine MA/Cr ratio,blood pressure,and TCM syndrome score after treatment（ P〈0. 05）; however,no significant difference was observed in abdominal circumference between the two groups（ P〉0. 05）. Conclusion： Huoxue Qianyang prescription combined with conventional Western medicine therapy has better efficacy than conventional Western medicine therapy alone in the treatment of obesity-related hypertension with abnormal urine MA/Cr ratio,and it can significantly improve the blood pressure and TCM symptoms of patients.

关 键 词：原发性高血压病 尿MA/Cr 腹型肥胖 中西医结合疗法 活血潜阳方 

分 类 号：R259.441.5[医药卫生—中西医结合]