连花清瘟胶囊联合左氧氟沙星治疗肺炎的临床研究  

Clinical study on Lianhua Qingwen Capsules combined with levofloxacisn in treatment of pneumonia

作　　者：吕宏[1] 欧阳张宁[1] 王俊[1] 杨刚[1] LV Hong;Ouyang Zhang-ning;WANG Jun;YANG Gang(Department of Respiratory Medicine,Jiangyou People＇s Hospital,Jiangyou 621700,China)

机构地区：[1]江油市人民医院呼吸内科,四川江油621700

出　　处：《现代药物与临床》2018年第9期2294-2297,共4页Drugs & Clinic

摘　　要：目的研究连花清瘟胶囊联合盐酸左氧氟沙星胶囊治疗肺炎的临床疗效。方法选取江油市人民医院2015年10月—2017年10月收治的120例肺炎患者为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组口服盐酸左氧氟沙星胶囊,2粒/次,2次/d;治疗组患者在对照组治疗的基础上口服连花清瘟胶囊,4粒/次,3次/d。两组患者均连续治疗14 d。观察两组患者的临床疗效,比较治疗前后两组患者的咳嗽消失时间、发热消退时间、肺部啰音消失时间和血清细胞因子水平。结果治疗后,对照组和治疗组的总有效率分别为83.33%、96.67%,两组比较差异有统计学意义(P<0.05)。治疗后,治疗组患者咳嗽消失时间、发热消退时间和肺部啰音消失时间均短于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者肿瘤坏死因子-α(TNF-α)、超敏反应C蛋白(hs-CRP)和白介素-4(IL-4)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);且治疗后治疗组血清细胞因子水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论连花清瘟胶囊联合盐酸左氧氟沙星胶囊治疗肺炎具有较好的临床疗效,能够显著改善患者的临床症状和炎性因子水平,安全性较高,具有一定的临床推广价值。Objective To study the clinical effect of Lianhua Qingwen Capsules combined with Levofloxacin Hydrochloride Capsules in treatment of pneumonia. Methods Patients（120 cases） with pneumonia in Jiangyou People’s Hospital from October 2015 to October 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Levofloxacin Hydrochloride Capsules, 2 grains/time, twice daily. Patients in the treatment group were po administered with Lianhua Qingwen Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacy was evaluated, and the time of cough disappearance, fever clearance time, the time of pulmonary rale disappearance, and the serum cytokine levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 83.33% and 96.67%, respectively, and there were differences between two groups（P 〈 0.05）. After treatment, the time of cough disappearance, fever clearance time, and the time of pulmonary rale disappearance in the treatment group were significantly shorter than those in the control group, with significant difference between two groups（P 〈 0.05）. After treatment, the levels of TNF-α, hs-CRP, and IL-4 in two groups were significantly decreased, and the difference was statistically significant in the same group（P 〈 0.05）. And the levels of serum cytokine levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P 〈 0.05）. Conclusion Lianhua Qingwen Capsules combined with Levofloxacin Hydrochloride Capsules has clinical curative effect in treatment of pneumonia, can significantly improve the clinical symptoms and inflammatory factor levels of patients, with good safety, which has a certain clinical application value.

关 键 词：连花清瘟胶囊 盐酸左氧氟沙星胶囊 肺炎 咳嗽消失时间 发热消退时间 肺部啰音消失时间 血清细胞因子 

分 类 号：R974[医药卫生—药品]