鼠神经生长因子联合银杏叶胶囊治疗糖尿病周围神经病变的疗效观察  

Clinical observation of mouse nerve growth factor combined with Yinxingye Capsules in treatment of diabetic peripheral neuropathy

作　　者：王小丽[1] 陈铅琴 李小荣 邢诒雄[1] 陈娟 陈文家 邓雪莲 李志伟[3] WANG Xiao-li;CHEN Qian-qin;LI Xiao-rong;Xing Yi-xiong;CHEN Juan;CHEN Wen-jia;DENG Xue-lian;LI Zhi-wei(Department of Pharmacy,the Third People＇s Hospital of Hainan Province,Sanya 572000,China;Department of Endocrinology,the Third People＇s Hospital of Hainan Province,Sanya 572000,China;Department of Radiology,the Third People＇s Hospital of Hainan Province,Sanya 572000,China)

机构地区：[1]海南省第三人民医院药剂科,海南三亚572000 [2]海南省第三人民医院内分泌科,海南三亚572000 [3]海南省第三人民医院放射科,海南三亚572000

出　　处：《现代药物与临床》2018年第9期2409-2413,共5页Drugs & Clinic

摘　　要：目的探讨注射用鼠神经生长因子联合银杏叶胶囊治疗糖尿病周围神经病变的临床疗效。方法选取2016年5月—2017年5月海南省第三人民医院收治的64例糖尿病周围神经病变患者为研究对象,按就诊先后顺序编号并按照奇偶数的形式随机分为对照组和治疗组,每组各32例。对照组患者口服银杏叶胶囊,1~2粒/次,3次/d。治疗组在对照组治疗的基础上肌肉注射注射用鼠神经生长因子,1瓶/d,加入2 m L注射水溶解,1次/d。两组患者均持续治疗2周。观察两组临床疗效,比较治疗前后两组患者的神经评分、运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)和血液流变学指标。结果治疗后,对照组和治疗组的临床总有效率分别为78.1%、96.9%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者神经症状评分、神经体征评分均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组神经评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者正中神经、腓总神经的MNCV和SNCV均显著升高,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组MNCV、SNCV明显高于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组全血黏度、血浆黏度、红细胞压积、血沉均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组血液流变学指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论注射用鼠神经生长因子联合银杏叶胶囊治疗糖尿病周围神经病变具有较好的临床疗效,可改善血液流变学等指标,提升患者生活质量,具有一定的临床推广应用价值。Objective To investigate the clinical effect of Mouse Nerve Growth Factor for Injection combined with Yinxingye Capsules in treatment of diabetic peripheral neuropathy. Methods Patients（64 cases） with diabetic peripheral neuropathy in the Third People’s Hospital of Hainan Province from May 2016 to May 2017 were randomly divided into control and treatment groups, and each group had 32 cases. Patients in the control group were po administered with Yinxingye Capsules, 1 — 2 grains/time, three times daily. Patients in the treatment group were im administered with Mouse Nerve Growth Factor for Injection on the basis of the control group, added 2 m L sterile water for injection to dissolve, 1 bottle/time, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the neurological scores, MNCV, SNCV, and hemorrheology indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 78.1% and 96.9%, respectively, and there were differences between two groups（P 〈 0.05）. After treatment, neurological symptom scores and neurological signs scores in two groups were significantly decreased, and the difference was statistically significant in the same group（P 〈 0.05）. After treatment, the neurological scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P 〈 0.05）. After treatment, the MNCV and SNCV of the median nerve and common peroneal nervous in two groups were significantly increased, and the difference was statistically significant in the same group（P 〈 0.05）. After treatment, the MNCV and SNCV in the treatment group were significantly higher than those in the control group, with significant difference between two groups（P 〈 0.05）. After treatment, whole blood viscosity, plasma viscosity, hematocrit, and erythrocyte sedimentation rate in two groups were s

关 键 词：注射用鼠神经生长因子 银杏叶胶囊 糖尿病周围神经病变 神经评分 运动神经传导速度 感觉神经传导速度 血液流变学指标 

分 类 号：R977[医药卫生—药品]