微重力及模拟微重力对微生物遗传变异、致病性与抗性的影响  

Effects of microgravity and simulated microgravity on genetic variation,pathogenicity and resistance of microorganisms

作　　者：黄兵[1] 赵忺 金显知 刘长庭[1] HUANG Bing;ZHAO Xian;JIN Xianzhi;LIU Changting(Department of Geriatric Respiratory Diseases,Chinese PLA General Hospital,Beijing 100853,China;Experimental class of Science and Technology,Beijing No.4 Middle School,Beijing 100034,China)

机构地区：[1]解放军总医院南楼呼吸科,北京100853 [2]北京四中科技实验班,北京100034

出　　处：《解放军医学院学报》2018年第9期809-813,825,共6页Academic Journal of Chinese PLA Medical School

基　　金：国家重点基础研究发展计划(973计划)(2014CB744400);国家科技重大专项项目(2015ZX09J15102-003);第60批中国博士后科学基金面上项目(2016M602971);军事医学重大工程项目(BWS17C030)~~

摘　　要：空间环境中的微重力能够影响微生物染色体及染色体外DNA的稳定性,影响基因组及重组蛋白的表达,使微生物致病性及抗性发生改变。本文就目前微重力和模拟微重力对微生物产生效应的分子机制及其对人体影响的研究进展进行综述。Microgravity in space environment can affect the stability of microbial chromosomes and other DNA, and the expression of genome and recombinant proteins. It will also lead to mutation, which may change their pathogenicity and resistance. This review summarizes the current research progress in molecular mechanisms of microgravity on microbes and their impacts on humans.

关 键 词：微重力 模拟微重力 微生物 遗传变异 致病性 抗性 

分 类 号：R85[医药卫生—航空、航天与航海医学]