血清Vit A、Vit E及IL-5与婴幼儿哮喘的相关性研究  

Correlation between serum Vit A,Vit E and IL-5 and asthma in infants

作　　者：王军 王艳 孙云 李磊 WANG Jun;WANG Yan;SUN Yun;LI Lei(Department of Pediatrics,Yinchuan Maternal and Child Health Care Center,Yinchuan 750001,China)

机构地区：[1]宁夏银川市妇幼保健院普儿科,宁夏银川750001

出　　处：《宁夏医学杂志》2018年第9期798-800,共3页Ningxia Medical Journal

基　　金：宁夏自然科学基金项目(NZ16228)

摘　　要：目的检测哮喘患儿血清中维生素A(Vit A)、维生素E(Vit E)及细胞因子白介素5(IL-5)的水平,通过病例对照探讨血清Vit A、Vit E及IL-5水平与婴幼儿哮喘发生、发展的相关性。方法对收治的100例哮喘患儿及150例健康婴幼儿进行Vit A、Vit E、IL-5检测,对检测结果进行比较分析。结果婴幼儿哮喘组均存在Vit A缺乏,且Vit A、Vit E水平均较对照组减低(P <0. 05),IL-5水平较对照组明显升高(P <0. 05)。IL-5水平与Vit A水平呈负相关,与Vit E水平无明显相关。结论 Vit A缺乏是发生婴幼儿支气管哮喘的病因之一,其血清浓度降低引起IL-5的异常分泌。Vit E水平减低是婴幼儿支气管哮喘发生、发展的相关营养素。补充Vit A、Vit E可降低婴幼儿哮喘发生率。Objective To detect the serum levels of vitamin A（Vitamin A,Vit A）,vitamin E（Vitamin E,Vit E） and cytokines interleukin 5（IL-5） in children with asthma,and to investigate the correlation between the level of serum Vit A,Vit E and IL-5 and the occurrence and development of infant asthma by case control. Methods 100 children with asthma and 150 healthy infants treated in Yinchuan Maternal and Child Health-Care Center and the Vit A,Vit E and IL-5 were examined and the results were compared and analyzed. Results The vitamin A deficiency was found in all the children with asthma,and the levels of vitamin A and E were lower than those in control group（P 0. 05）,and the level of IL-5 was significantly higher than that in the control group（P 0. 05）. IL-5 level was negatively correlated with Vit A,and had no significant correlation with vitamin E level. Conclusion The lack of Vit A is one of the causes of bronchial asthma in infants. The decrease of serum concentration causes abnormal secretion of IL-5. The decrease of Vit E level is related to the occurrence and development of bronchial asthma in infants. Therefore,supplementation of Vit A and Vit E can reduce the incidence of asthma in infants.

关 键 词：婴幼儿哮喘 维生素 细胞因子白介素5 免疫 

分 类 号：R725.6[医药卫生—儿科]