Cell-based drug delivery systems for biomedical applications  

作　　者：Teng Li He Dong Can Zhang Ran Mo 

机构地区：[1]State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of AdvancedPharmaceuticals and 8iomaterials, China Pharmaceutical University, Nanjing 210009, China

出　　处：《Nano Research》2018年第10期5240-5257,共18页纳米研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （No. 81673381）, the Natural Science Foundation of Jiangsu Province of China for Distinguished Young Scholars （No. BK20150029）, the Program for Jiangsu Province Innovative Research Talents, and the Program for Jiangsu Province Innovative Research Team.

摘　　要：Spurred by numerous achievements in nanoscience and nanotechnology, the evolution of nanoparticulate drug delivery systems （nano-DDSs） is in its rapid growth period and attracting considerable attention due to their unique advantages in biomedical applications. Natural particulates ranging from mammalian cells to bacteria possess their own distinctive delivery processes and mechanisms, which inspires more design and development of cell-based DDSs by integrating the innate functions of cells with the nanoscale characteristics of nanoparticles. In this review article, we focus on the recent advances in cell-based DDSs for site-specific delivery of therapeutics and enhanced treatment of diseases. The promise and perils of cell-based DDSs are also discussed.Spurred by numerous achievements in nanoscience and nanotechnology, the evolution of nanoparticulate drug delivery systems （nano-DDSs） is in its rapid growth period and attracting considerable attention due to their unique advantages in biomedical applications. Natural particulates ranging from mammalian cells to bacteria possess their own distinctive delivery processes and mechanisms, which inspires more design and development of cell-based DDSs by integrating the innate functions of cells with the nanoscale characteristics of nanoparticles. In this review article, we focus on the recent advances in cell-based DDSs for site-specific delivery of therapeutics and enhanced treatment of diseases. The promise and perils of cell-based DDSs are also discussed.

关 键 词：natural particulates NANOTECHNOLOGY BIOINSPIRED drug delivery biomedical application 

分 类 号：TB383[一般工业技术—材料科学与工程] TP317[自动化与计算机技术—计算机软件与理论]