Selenium-functionalized metal-organic frameworks as enzyme mimics  

作　　者：Weiqiang Zhou Hongfeng Li Bin Xia Wenlan Ji Shaobo Ji Weina Zhang Wei Huang Fengwei Huo Huaping Xu 

机构地区：[1]Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (Nanjing Tech), Nanjing 211816, China [2]Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China

出　　处：《Nano Research》2018年第10期5761-5768,共8页纳米研究（英文版）

基　　金：The project was supported by the National Natural Science Foundation of China for Distinguished Young Scholars （Nos. 21425416 and 21625401）, the Foundation for Innovative Research Groups of the National Natural Science Foundation of China （No. 21421064）, the National Natural Science Foundation of China （Nos. 21574065, 21504043 and 21604038）, the Jiangsu Provincial Founds for Distinguished Young Scholars （No. BK20140044） and NSF （No. BK20160975）, the Program for Outstanding Young Scholars from the Organization Department of the CPC Central Committee, and the National Key Basic Research Program of China （Nos. 2013CB834502 and 2015CB932200）.

摘　　要：The development of artificial enzyme mimics has been rapidly growing in recent years, and it is attracting increasing attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate efficient glutathione peroxidase （GPx） mimics by grafting selenium-containing molecules （phenylselenylbromide, PhSeBr） to a Zr（W）-based UiO-66-NH2 framework. In the presence of glutathione （GSH） serving as substrate, the fabricated UiO-66-Se catalysts can catalyze the reduction of hydroperoxides. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. These high-efficiency GPx mimic metal-organic frameworks （MOFs） are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.The development of artificial enzyme mimics has been rapidly growing in recent years, and it is attracting increasing attention owing to their remarkable advantages over natural enzymes. Herein, we developed a general and facile method to fabricate efficient glutathione peroxidase （GPx） mimics by grafting selenium-containing molecules （phenylselenylbromide, PhSeBr） to a Zr（W）-based UiO-66-NH2 framework. In the presence of glutathione （GSH） serving as substrate, the fabricated UiO-66-Se catalysts can catalyze the reduction of hydroperoxides. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. These high-efficiency GPx mimic metal-organic frameworks （MOFs） are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.

关 键 词：metal-organic frameworks nano chemistry selenium chemistry enzyme mimic postsynthetic modification 

分 类 号：TQ464.7[化学工程—制药化工] TU375.4[建筑科学—结构工程]