2,6-二取代吡喃类化合物的合成研究  

Synthesis Research of 2,6-Disubstituted Pyran Compounds

作　　者：施梅 陈昌云 陈红 SHI Mei;CHEN Chang-yun;CHEN Hong(School of Environmental Science,Nanjing Xiaozhuang University,Nanjing 211171,China)

机构地区：[1]南京晓庄学院环境科学学院

出　　处：《化学试剂》2018年第10期931-936,1001,共7页Chemical Reagents

基　　金：国家自然科学基金资助项目(21671107);南京晓庄学院自然科学基金资助项目(2017NXY44)

摘　　要：开发了一种构建2,6-二取代吡喃类骨架的新方法。以糠醛和炔丙基溴为原料,其加成产物分别与正辛醛、异丁醛、苯甲醛及对甲基苯甲醛先后经亲核加成、催化氢化及酸催化环合等反应,合成6个目标化合物。经~1HNMR、13CNMR、HR-MS和元素分析确证了目标化合物及反应中间体的结构。该方法高效、简便且收率高。A novel approach was developed to construct 2,6-disubstitutedpyran framework. Six new 2,6-disubstituted pyran compounds were synthesized from the addition product of furfural and propargyl bromide via three steps including nucleophilic addition,catalytic hydrogenation and acid-catalyzed cyclization. The target compounds and the key intermediates were confirmed by ~1HNMR,13CNMR,HR-MS and elemental analysis.This method is efficient,facile and high-yielding.

关 键 词：吡喃 2 6-二取代 合成 亲核加成 催化氢化 酸催化环合 

分 类 号：O626.3[理学—有机化学]