^(14)C呼气试验对武昌地区健康体检人群Hp感染的检测价值  

Research on detection value of ^(14)C-urea breath test for Helicobacter pylori infection in health check-up population of Wuchang District

作　　者：高彦荣[1] 何青峰[1] 王丽江[1] 陈宁[1] 陈瑛[1] GAO Yan-rong;HE Qing-feng;WANG Li-jiang;CHEN Ning;CHEN Ying(Wuhan Third Hospital（Affiliated Hospital of Wuhan University）,Wuhan,Hubei 430060,China)

机构地区：[1]武汉市第三医院(武汉大学附属同仁医院)首义院区体检中心,湖北武汉430060

出　　处：《中华医院感染学杂志》2018年第19期2961-2963,2984,共4页Chinese Journal of Nosocomiology

基　　金：湖北省自然科技基金资助项目(20170928883)

摘　　要：目的探讨^(14)C呼气试验对武昌地区健康体检人群幽门螺杆菌(Helicobacter pylori,Hp)感染的检测价值。方法选择2016年10月-2017年10月于医院进行健康体检的1 000例体检者为研究对象,所有体检者均接受^(14)C呼气试验,对Hp的感染情况进行分析,并对不同性别、年龄及烟酒嗜好等情况下的检测情况进行比较。结果 1 000例健康体检者中共检出Hp阳性者561例,阳性率为56.10%,其中570例男性中Hp阳性者324例,阳性率为56.84%,430例女性中Hp阳性者238例,阳性率为55.35%,差异无统计学意义;Hp阳性者集中于35～45岁,阳性率为76.61%(95/124),46～55岁Hp阳性率为57.43%(85/148),56～65岁Hp阳性率为54.30%(164/302),66～75岁Hp阳性率为51.88%(138/266),76～85岁年龄段Hp阳性率最低为49.38%(79/160),Hp阳性率表现为各年龄段间差异有统计学意义(P<0.05),Hp阳性率表现出随着年龄增长而逐渐降低的趋势(P<0.001);有吸烟、经常饮酒及有烟酒(经常饮酒)者分别相比无吸烟、偶尔饮酒或无饮酒及无烟酒(偶尔饮酒)者Hp阳性率高(P<0.001)。结论 ^(14)C呼气试验对健康体检人群Hp感染具有重要指导意义,且Hp感染率在中年人群及有烟酒嗜好者中具有较高的检出率。OBJECTIVE To study the detection value of 14C-urea breath test for Helicobacter pylori infection in health check-up population of Wuchang District.METHODS 1 000 cases of health check-up population with physical examination carried out in our hospital from Oct.2016 to Oct.2017 were selected as the research objects.All accepted 14C-urea breath test,and were analyzed for H.pylori infection.The test results were compared between populations with different gender,age,and with or without tobacco and alcohol addiction.RESULTS 561 cases of person were detected with Hp positivity in a total of 1000 cases of healthy people,and the positive rate was 56.10%.There were 324 cases of men detected with Hp positivity in 570 cases of male subjects,with a positive rate of 56.84%.There were 238 cases of women detected with Hp positivity in 430 cases of female subjects,with a positive rate of 55.35%.The comparison between groups showed that the differences between men and women in the Hp positive detection rate had significance.After grouping according to different age,the Hp positive subjects were focused in the range of 35 to 45 years old,with a positive rate of 79.61%（95/124）,the Hp positive rate of 46 to 55 years old subjects was 57.43%（85/148）,the Hp positive rate of 56 to 65 years old subjects was 54.30%（164/302）,the Hp positive rate of 66-66 years old subjects was 51.88%（138/266）,and the lowest Hp positive rate was observed with 76-85 years old subjects,which was 49.38%（79/160）.The Hp positive rate between groups showed that the differences were significant（P〈0.05）.After grouping according to tobacco and alcohol addiction,the Hp positive rates of subjects that smoke,often drink,or with tobacco and alcohol addiction were obviously higher than those that do not smoke,seldom or never drink,and without tobacco and alcohol addiction（P〈0.001）.The differences between groups were significant（P〈0.001）.CONCLUSION 14C-urea breath test had important guiding significance for Hp infection detection in t

关 键 词：^14C呼气试验 幽门螺旋杆菌 健康体检 

分 类 号：R378[医药卫生—病原生物学]