急性冠脉综合征患者PCI手术后Hp感染相关因素分析  

Risk factors of Helicobacter pylori infection in patients with acute coronary syndrome after PCI

作　　者：朱便茹[1] 崔树梅 崔国峰[2] ZHU Bian-ru;CUI Shu-mei;CUI Guo-feng(Affiliated Hospital of Inner Mongolia Medical University,Hohhot,Inner Mongolia 010050,China)

机构地区：[1]内蒙古医科大学附属医院病案室,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院心内科,内蒙古呼和浩特010050

出　　处：《中华医院感染学杂志》2018年第19期2981-2984,共4页Chinese Journal of Nosocomiology

基　　金：呼和浩特市科技局科研基金资助项目(20150411)

摘　　要：目的探讨急性冠脉综合征患者冠状动脉介入手术(PCI)后幽门螺杆菌(Hp)感染的相关因素。方法回顾性分析2015年1月-2017年1月于医院接受PCI治疗的急性冠脉综合征患者300例和同期未接受PCI治疗的急性冠脉综合征患者245例的临床资料,将接受PCI患者设为研究组,未接受PCI治疗患者设为对照组;观察两组患者治疗后3个月、6个月后的消化道出血问题;分析接受PCI治疗患者的年龄、性别、高血压史、高血脂史、糖尿病史及质子泵抑制剂药物(Proton pump inhibitor,PPI)服用史等临床资料,归纳急性冠脉综合征患者PCI术后Hp感染的相关因素。结果研究组患者Hp感染率为69.67%(209/300)高于对照组51.84%(127/245)(P=0.026);感染组患者治疗后消化道出血率为15.79%(33/209)高于对照组患者的9.45%(12/127)(P=0.033);年龄、消化性溃疡史、PPI药物服用史、血肌酐升高是急性冠脉综合征患者PCI术后Hp感染的相关因素(P<0.05)。结论急性冠脉综合征患者PCI术后Hp感染率高于未接受PCI手术患者,且发生出血问题的风险较高,临床应尽早检测、针对相关因素采取相应措施。OBJECTIVE To investigate the risk factors of Helicobacter pylori（Hp）infection in patients with acute coronary syndrome after percutaneous coronary intervention（PCI）.METHODS The clinical data of 300 patients with acute coronary syndrome treated with PCI and 245 cases of acute coronary syndromes without PCI enrolled in the hospital from Jan.2015 to Jan.2017 were retrospectively analyzed.The patients received PCI were set as the study group,and the patients who had not received the PCI treatment were set as the control group;the two groups of patients were treated for 3 months and 6 months after treatment.The problems of gastrointestinal bleeding after a month were analyzed,and the clinical data of age,gender,history of hypertension,hyperlipidemia,diabetes history and Proton pump inhibitor（PPI）were analyzed for patients with PCI,and the related factors of Hp infection in patients with acute coronary syndrome after PCI were analyzed.RESULTS The rate of Hp infection in the study group was 69.67%（209/300）,significantly higher than that of the control group 51.84%（127/245）（P=0.026）.The bleeding rate of the digestive tract was 15.79%（33/209）after treatment in the infection group,significantly higher than that of the control group which was 9.45%（12/127）（P=0.033）,and the age,the history of peptic ulcer,the history of PPI medication,and the increase of serum creatinine were risk factors of Hp infection after PCI in patients with syndrome of acute coronary arteries（P〈0.05）.CONCLUSIONThe incidence of Hp infection in patients with acute coronary syndrome after PCI is higher than that of patients who have not received PCI surgery,and the risk of bleeding is higher.The clinical measures should be taken as early as possible and the relevant factors should be taken into account.

关 键 词：急性冠脉综合征 经皮冠状动脉介入治疗 幽门螺旋杆菌 消化道出血 

分 类 号：R619.3[医药卫生—外科学]