泮托拉唑对老年高血压合并糖尿病患者阿司匹林相关消化性溃疡的疗效和安全性  

Efficacy and safety of pantoprazole in the treatment of aspirin related peptic ulcers in elderly hypertensive patients with diabetes mellitus

作　　者：李建君[1] 彭兰[1] LI Jian-jun;PENG Lan(Department of Internal Medicine,Sichuan Integrative Medicine Hopital,Chengdou 610041,China)

机构地区：[1]四川省中西医结合医院内科,四川成都610041

出　　处：《河北医科大学学报》2018年第11期1249-1252,共4页Journal of Hebei Medical University

摘　　要：目的系统评价泮托拉唑对老年高血压合并糖尿病患者阿司匹林相关消化性溃疡的疗效和安全性。方法选择老年高血压合并糖尿病患者因长期服用阿司匹林导致消化性溃疡98例,随机分为观察组(泮托拉唑治疗)和对照组(雷尼替丁治疗),治疗4周后行内镜检查,并继续治疗于6个月后随访,对比2组出现消化道不适症状和胃镜下黏膜表现变化,以及主要心血管不良事件和不良反应等。结果治疗4周后观察组内镜下黏膜愈合总有效率(97.96%)高于对照组(83.67%),而观察组消化系统不适症状发生率(10.20%)和不良反应发生率(12.24%)明显低于对照组(26.53%,28.57%),差异均有统计学意义(P<0.05);治疗6个月后电话随访,观察组消化系统不适症状和不良反应发生率分别为8.16%和14.28%,低于雷尼替丁组的24.49%和32.65%,差异均有统计学意义(P<0.05)。结论泮托拉唑对老年高血压合并糖尿病患者阿司匹林相关消化性溃疡疗效显著且耐受性好,值得临床推广。Objective To evaluate the efficacy and safety of pantoprazole in the treatment of aspirin related peptic ulcers in elderly hypertensive patients with diabetes mellitus.Methods The elderly hypertensive patients（ n =98） with diabetes mellitus suffering peptic ulcer caused by low-dose aspirin were chosen, and then randomly divided into observation group and control group（each n =49）. The observation group was given pantoprazole and the control group was given ranitidine. Endoscopy was performed after 4 weeks treatment and telephone follow-up was performed after 6 months treatment. The gastrointestinal symptoms, changes in endoscopic mucosal, and adverse effects including major adverse cardiovascular events were compared between two groups.Results Endoscopic mucosal healing rate（97.96%） of the observation group was higher than that of the control group（83.67%）, and the incidence of gastrointestinal symptoms（10.20%） and the incidence of adverse reactions（12.24%） of the observation group were significantly lower than those of the control group（26.53%, 28.57%） after 4 weeks of treatment（ P 〈 0.05）. The incidence of gastrointestinal symptoms and adverse reactions in the observation group was 8.16% and 14.28% respectively,which were lower than those of the control group（24.49%, 32.65%） after 6 months treatment （ P 〈 0.05）.Conclusion Pantoprazole is effective and tolerable in the treatment of aspirin related peptic ulcer in elderly hypertensive patients with diabetes mellitus. It is worthy of clinical promotion.

关 键 词：高血压 糖尿病 消化性溃疡 

分 类 号：R544.1[医药卫生—心血管疾病] R587.1[医药卫生—内科学]