亚洲人群肿瘤发病与人类端粒酶逆转录酶rs2736100位点相关性的Meta分析  

Association between hTERT gene single nucleotide polymorphism rs2736100 loci and tumor susceptibility in Asian populations:a Meta-analysis

作　　者：秦通 韩振伟[1] 滕志海[1] 常学良[1] 李景东[1] 王亚轩[1] QIN Tong;HAN Zhen-wei;TENG Zhi-hai;CHANG Xue-liang;LI Jing-dong;WANG Ya-xuan(Department of Urology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院泌尿外科,河北石家庄050000

出　　处：《河北医科大学学报》2018年第11期1304-1310,共7页Journal of Hebei Medical University

摘　　要：目的探讨人端粒酶逆转录酶(human telomerase reverse transcriptase,hTERT)基因多态性(rs2736100)与亚洲人群肿瘤的关系。方法在中英文数据库中,依据纳入和排除标准,按关键词全面搜索文献,筛选出符合要求的文献,运用Stata 12.0统计软件对提取的数据进行合并分析,计算合并的优势比(odds ratio,OR)及其95%置信区间(95%confidence interval,95%CI)。结果本研究共纳入了34个病例对照研究,共涉及肿瘤患者47 148例和对照75 673例。Meta分析结果显示,hTERT基因rs2736100多态性可显著升高亚洲人群肿瘤遗传易感性,(B vs A,OR=1.25,95%CI=1.20～1.29,P=0.000),(BB vs AA,OR=1.56,95%CI=1.45～1.67,P=0.000),(AB vs AA,OR=1.22,95%CI=1.17～1.28,P=0.000),(AB+BB vs AA,OR=1.30,95%CI=1.24～1.37,P=0.000),(BB vs AB+AA,OR=1.39,95%CI=1.32～1.47,P=0.000),其中肺癌患者36 815例,对照64 149例。Meta分析结果显示,hTERT基因rs2736100多态性可显著升高亚洲人群肺癌遗传易感性[(B vs A,OR=1.28,95%CI=1.23～1.32,P=0.000),(BB vs AA,OR=1.64,95%CI=1.52～1.76,P=0.001),(AB vs AA,OR=1.27,95%CI=1.21～1.33,P=0.015),(AB+BB vs AA,OR=1.35,95%CI=1.28～1.42,P=0.001),(BB vs AB+AA,OR=1.42,95%CI=1.35～1.50,P=0.030)]。结论在亚洲人群中,hTERT基因rs2736100多态性是肿瘤易感性增加的危险因素。Objective To investigate the relationship between human telomerase reverse transcriptase（hTERT） gene polymorphism rs2736100 and tumor in Asian population.Methods According to the inclusion and exclusion criteria, relevant literature were searched based on key words in Chinese and English databases. Documents that met the requirements were screened, and related data were extracted. Stata 12.0 statistical software was used to merge and analyze the extracted data. Meanwhile, odds ratio（ OR ） and its 95% confidence interval（95% CI ） were calculated.Results Totally 34 case-control studies were included, including 47 148 tumor patients and 75 673 controls. Meta-analysis results showed that hTERT gene polymorphism rs2736100 could significantly increase tumor genetic susceptibility in Asian populations（B vs A, OR = 1.25,95% CI =1.20-1.29, P = 0.000）, （BB vs AA, OR = 1.56, 95% CI =1.45-1.67, P = 0.000）, （AB vs AA, OR = 1.22, 95% CI =1.17-1.28, P = 0.000）, （AB＋BB vs AA, OR = 1.30 , 95% CI =1.24- 1.37 , P = 0.000）, （BB vs AB＋AA, OR = 1.39, 95% CI =1.32-1.47, P = 0.000）. Moreover, 36 815 lung cancer patients and 64 149 controls were included in this study. Meta-analysis results indicated that rs2736100 could significantly increase lung cancer susceptibility in Asian populations（B vs A, OR = 1.28, 95% CI =1.23-1.32, P = 0.000）, （BB vs AA, OR = 1.64, 95% CI =1.52- 1.76 , P = 0.001）, （AB vs AA, OR = 1.27, 95% CI =1.21- 1.33 , P = 0.015）, （AB＋BB vs AA, OR = 1.35, 95% CI =1.28-1.42, P = 0.001）, （BB vs AB＋AA, OR = 1.42, 95% CI =1.35-1.50, P = 0.030）.Conclusion In Asian populations,rs2736100 polymorphism of hTERT gene is a risk factor for tumor susceptibility.

关 键 词：肿瘤 逆转录聚合酶链反应 端粒酶 META分析 

分 类 号：R370.2[医药卫生—病原生物学]