生长抑素联合白蛋白注射液治疗急性胰腺炎临床疗效及安全性研究  

Clinical efficacy and safety of somatostatin combined with albumin injection in the treatment of acute pancreatitis

作　　者：陈莹[1] 李继昌[1] 剡建华 刘海霞[1] 吴育美[1] 薛挺[1] Chen Ying;Li Jichang;Yan Jianhua(Baoji Central Hospital in Shaanxi Province,Baoji 721008)

机构地区：[1]陕西省宝鸡市中心医院,宝鸡721008 [2]陕西省咸阳市中心医院,咸阳712000

出　　处：《陕西医学杂志》2018年第11期1487-1489,1506,共4页Shaanxi Medical Journal

摘　　要：目的:探讨生长抑素联合白蛋白注射液治疗急性胰腺炎(SAP)的临床效果及安全性。方法:将符合纳入排除标准的120例SAP患者均分为两组,对照组在常规治疗基础上加用生长抑素进行治疗;试验组则加用生长抑素与白蛋白注射液进行联合治疗。记录两组腹胀、腹痛消退时间、血清淀粉酶水平恢复时间及住院时间;测定两组患者治疗前后血清白蛋白、血小板活化因子(PAF)、C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α);对比两组并发症及不良反应发生情况。结果:试验组临床总有效率为95.00%,对照组81.67%,两组间差异存在统计学意义(P<0.05)。与对照组比,试验组腹痛腹胀消失、血清淀粉酶水平恢复及平均住院时间均明显缩短(P<0.05),血清白蛋白上升及血清炎症因子PAF、CRP、IL-6、TNF-α水平下降程度更明显(P<0.05),胰腺脓肿及胰腺假性囊肿发生率均明显减少(P<0.05);但两组急性肾衰竭、腹腔感染发病率及不良反应发生率间差异无统计学意义(P>0.05)。结论:与单独使用生长抑素相比,生长抑素与白蛋白注射液联合治疗SAP效果更好,可更好的抑制机体炎症因子释放,改善患者局部血流动力学,预防并发症发生,且安全性良好。ObjectiveTo investigate the clinical efficacy and safety of somatostatin combined with albumin injection in the treatment of acute pancreatitis （SAP）.Methods：120 SAP patients who met the exclusion criteria were divided into two groups. The control group was treated with somatostatin on the basis of routine treatment.The experimental group was treated with somatostatin combined with albumin injection.The time of bloating, abdominal pain subsided, serum amylase recovery and hospital stay was recorded in two groups.The levers of serum albumin, platelet activating factor （PAF）, C-reactive protein （CRP）, interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） were measured before and after treatment in the two groups.The complications and adverse reactions were compared in the two groups.Results：The total clinical effective rate was 95.00% in the experimental group and 81.67% in the control group,and there was a statistically significant difference between the two groups （ P 〈0.05）.Compared with the control group, the time of abdominal pain disappearance, recovery of serum amylase and average length of stay was significantly shorter in the experimental group （ P 〈0.05）;Serum albumin increased more significantly （ P 〈0.05）, serum inflammatory factors of PAF, CRP, IL-6, TNF-α levels decreased more significantly（ P 〈0.05）;The incidence of pancreatic abscesses and pancreatic pseudocysts was significantly reduced （ P 〈0.05）.However, there was no significant difference in the incidence of acute renal failure, abdominal infection, and incidence of adverse reactions between the two groups （ P 〉0.05）.Conclusion：Compared with somatostatin alone, somatostatin combined with albumin injection has better effect on SAP, which can better inhibit the release of body inflammatory factors, improve local hemodynamics, prevent complications, and safety good.

关 键 词：胰腺炎 急性坏死性/药物疗法生 长抑素/治疗应用 白蛋白/治疗应用 

分 类 号：R657.51[医药卫生—外科学]