新型吡啶联吡唑双酰肼类化合物的合成及除草活性  

Synthesis and Herbicidal Activities of Novel Pyridine Substituted Pyrazole Diacylhydrazine Derivatives

作　　者：谭悦[1] 何海琴[1] 刘幸海[1] 翁建全[1] 谭成侠[1] TAN Yue;HE Hai-qin;LIU Xing-hai;WENG Jian-quan;TAN Cheng-xia(College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014,China)

机构地区：[1]浙江工业大学化学工程学院,浙江杭州310014

出　　处：《合成化学》2018年第10期727-732,共6页Chinese Journal of Synthetic Chemistry

基　　金：国家科技支撑计划课题(2011BAE06B03-1)

摘　　要：以乙酰丙酮和溴乙酸乙酯等为起始原料,经取代、肼基化、环合、水解、酸化和缩合等反应合成了12个新型的吡啶联吡唑双酰肼类化合物(1a^1l),其结构经~1H NMR,^(13)C NMR和MS(ESI)表征。并研究了化合物的除草活性。培养皿法测试结果表明:用药量为200 mg·L^(-1)时,1j,1k和1l对油菜的抑制率均为100%。盆栽法测试结果表明:苗后茎叶喷雾处理用药量为150 g·hm^(-2)时,1l对靶标杂草芥菜、繁缕的抑制率分别为80%和70%。Abstract： Twelve novel pyridyl substituted pyrazole diacylhydrazines derivatives（ la- 11） were syn- thesized from acetylacetone, ethyl bromoacetate by the reactions of substitution, alkylation, cyclization, hydrolysis, acidification and condensation, etc. The structures were characterized by 1H NMR, 13C NMR and MS（ESI） and the herbicidal acitivities were tested. The dish test results indicated that the inhibition rate of lj, lk and 11 against rape reached 100% with dosage of 200 mg · L^-1. The pot test results showed that the growth inhibition rate of 11 against Brassica juncea and Stellaria media were 80% and 70% , with dosage of 150 g·hm^-2（postemergence foliar spray processing）.

关 键 词：吡啶联吡唑 双酰肼 合成 培养皿法 盆栽法 除草活性 

分 类 号：O626.32[理学—有机化学]