pH敏感两亲性嵌段聚合物的合成及其对新型抗生物膜药物的控释研究  

Synthesis of A pH-Sensitive Amphiphilic Block Polymer and Its Application in Controlled Release of Novel Antibiofilm Drugs

作　　者：赵洲祥 丁春梅[1] ZHAO Zhou-xiang;DING Chun-mei(College of Polymer Science and Engineering,Siehuan University,Chengdu 610065,China)

机构地区：[1]四川大学高分子科学与工程学院,四川成都610065

出　　处：《合成化学》2018年第10期733-737,共5页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(51503126);北京化工大学化工资源有效利用国家重点实验室开放课题(CRE-2017-C-204)

摘　　要：采用ATRP技术,以PEG-Br为大分子引发剂,2-二异丙氨基乙基甲基丙烯酸酯(DPA)为单体,合成了一种pH敏感两亲性嵌段聚合物PEG-b-PDPA,其结构经1H NMR和GPC确证。采用超声乳化法制备了包载新型抗生物膜药物的聚合物载药胶束(1),并研究了其结构和性能。结果表明:1的粒径均一、结构稳定,载药率和包封率分别为13. 25%和79. 50%。在酸性条件下(pH 5. 5),1解组装并释放包裹在疏水"核层"的抗生物膜药物。A pH-sensitive amphiphilic block polymer PEG-b-PDPA was synthesized by ATRP method, using DPA as monomer, PEG-Br as macroinitiator. The structure was confirmed by ^1H NMR and GPC. The drug-loaded polymeric micelles（ 1 ） , which encapsulated novel antibiofilm dings, was prepared by ultrasonic emulsification method. The proper6es of 1 were investigated as well. The results indicated that 1 was stable and had a uniform size distribution. The loading efficiency and encapsulation efficiency were 13.25% and 79.50% , respectively. In addition, 1 disassembled and released antibiofilm drugs wrapped in hydrophobic core under acid condition（ pH 5.5 ）.

关 键 词：龋病 PH敏感 嵌段聚合物 合成 抗生物膜药物 控制释放 

分 类 号：O624.6[理学—有机化学]