速度向量成像技术在评价甲状腺功能亢进性心脏病大鼠心功能中的应用  

Evaluation of velocity vector imaging for cardiac function in rats with hyperthyroid heart disease

作　　者：侯睿 金铉顺[2] 高艺花 金成子 郑斯琴 马伟平[3] Rui HOB;Xuan-shun Jin;Yi-hua Gao;Cheng-zi Jin;Si-qin Zheng;Wei-ping Ma(Department of Ultrasonic Diagnosis;Department of Cardiology,Yanbian University Hospital,Yanji,Jilin 133000,China;Department of Pharmacology,Yanbian University Yanji Jilin 133000,China)

机构地区：[1]延边大学附属医院影像二科,吉林延吉133000 [2]延边大学附属医院心内科,吉林延吉133000 [3]延边大学药理学教研室,吉林延吉133000

出　　处：《中国现代医学杂志》2018年第30期7-10,共4页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:81660250);吉林省卫生技术创新项目(No:2017J094)

摘　　要：目的应用速度向量成像(VVI)评价甲状腺功能亢进性心脏病(甲亢性心脏病)大鼠心功能。方法复制甲亢性心脏病大鼠模型,经超声VVI软件、检测大鼠血清TT3和TT4水平及电镜观察超微结构评价甲亢性心脏病大鼠心功能。结果模型组的收缩期和舒张期纵向峰值速度(Vs、Vd)、纵向峰值应变(Sr)及收缩期和舒张期纵向峰值应变率均低于对照组(P <0.05)。与对照组比较,模型组血清T3、T4浓度增高(P <0.05)。对照组大鼠心肌组织电镜下示心肌结构无变化,未见增生的心肌纤维结构。模型组可见心肌间质纤维化。结论VVI技术对评价甲亢性心脏病心功能有重要作用。Objective To evaluate the cardiac function in rats with hyperthyroid heart disease by velocity vector imaging （VVI）. Methods Rat models of hyperthyroid heart disease were established. The levels of serum TT3, TT4 and electron microscopy in the minor changes of rats of hyperthyroid heart disease were detected by ultrasound VVI.Results The systolic and diastolic radial velocity （Vs, Vd）, radial strain （Sr）, systolic and diastolic radial strain rate（SRr） of model group were lower than control group （P 〈 0.05）. Serum TT3 and TT4 levels of model group wereincreased （P 〈 0.05） compared with the control group. There was no significant change for myocardial structure and no obvious hypertrophic myocardial fiber structure in the control group. The degree of myocardial interstitial fibrosis in the model group was significantly higher than that in the control group. Conclusion VVI plays an important role in evaluating the cardiac function of hyperthyroid heart disease.

关 键 词：速度向量成像技术 甲状腺功能亢进性心脏病 心功能 

分 类 号：R445.1[医药卫生—影像医学与核医学]