肿瘤标志物、PTTG、VEGFR-3及血流参数在宫颈病变中的价值  

Prognostic significance of PTTG, VEGFR-3 and hemodynamic index in cervical lesions

作　　者：吉洁[1] 申兴斌[2] 韩冰[3] 张玉娟[3] 马志君[4] Jie Ji;Xing-bin Shen;Bing Han;Yu-juan Zhang;Zhi-jun Ma(Department of Medical Record,the Southern Branch of the Affiliated Hospital of Chengde Medical University,Chengde,Hebei 067000,China;Department of Pathology;Department of Gynecology;Department of Neurosurgery,the Affiliated Hospital of Chengde MedicalUniversity,Chengde,Hebei 067000,China)

机构地区：[1]承德医学院附属医院南院区病案室,河北承德067000 [2]承德医学院附属医院病理科,河北承德067000 [3]承德医学院附属医院妇科,河北承德067000 [4]承德医学院附属医院神经外科,河北承德067000

出　　处：《中国现代医学杂志》2018年第30期26-31,共6页China Journal of Modern Medicine

基　　金：河北省承德市科技局项目(No:201121053)

摘　　要：目的探讨肿瘤标志物、垂体瘤转化基因(PTTG)、血管内皮生长因子受体3(VEGFR-3)及血流动力学指标在宫颈良恶性病变患者中的表达及临床意义。方法选取2012年3月-2016年2月该院收治且经病理确诊的98例宫颈病变患者的临床资料。所有患者术中均留取宫颈组织标本,入院后均采集血样,采用免疫组织化学法测定PPTG、VEGFR-3表达情况,并测定血清鳞状细胞癌抗原(SCC)、糖类抗原19-9(CA199)、糖类抗原125(CA125)水平,检测微血管密度(MVD)。采用多普勒超声测定收缩期峰值血流速度(PSV)、舒张末血流速度(EDV)及血管阻力指数(RI),分析宫颈良恶性病变患者上述指标的表达情况及临床意义。结果 (1)慢性宫颈炎患者SCC、CA199及CA125水平均低于宫颈上皮内瘤样病变(CIN)患者与宫颈浸润癌患者(P <0.05),CIN患者上述水平低于宫颈浸润癌患者(P<0.05);(2) CIN、宫颈浸润癌PTTG、VEGFR-3表达阳性率高于慢性宫颈炎(P <0.05),宫颈浸润癌PTTG、VEGFR-3表达阳性率高于CIN(P <0.05);(3)慢性宫颈炎MVD低于CIN、宫颈浸润癌(P <0.05),CIN MVD低于宫颈浸润癌(P <0.05);(4) CIN、宫颈浸润癌PSV、EDV均高于慢性宫颈炎(P <0.05),RI低于慢性宫颈炎(P <0.05),宫颈浸润癌PSV、EDV高于CIN,RI低于CIN(P <0.05)。结论宫颈浸润癌患者血清肿瘤标志物表达水平高,癌组织PTTG、VEGFR阳性率高、MVD高,血流速度快、血管阻力低,与宫颈良性病变患者有差异。Objective To investigate the expression and clinical significance of tumor markers, pituitary tumortransforming gene （PTTG）, vascular endothelial growth factor receptor -3 （VEGFR-3） and hemodynamic indexes in patients with benign or malignant cervical lesions. Methods Totally 98 patients with pathologically confirmed cervical lesions were admitted into our hospital from March 2012 to February 2016 and were involved in this study.Cervical tissuesand blood samples of all patients were collected. The expressions of PPTG and VEGFR-3 weredetermined by Immunohistochemistry. Levels of serum squamous cell carcinoma antigen （SCC）, carbohydrateantigen 19-9 （CA199）, carbohydrate antigen 125 （CA125）, microvessel density （MVD）, peak systolic velocity（PSV）, end diastolic velocity （EDV） and vascular resistance index （RI） were identified. Clinical significance of above-mentioned indexes in patients with benign or malignant lesions were analyzed. Results Levels of SCC,CA199 and CA125 in patients with cervical intraepithelial neoplasia （CIN） were increased compared with those in patients with chronic cervicitis（P 〈 0.05）,while those were downregulated when compared with patients with invasive cervical carcinoma （P 〈 0.05）. The positive expression rates of PTTG and VEGFR-3 in patients with cervical intraepithelial neoplasia （CIN） were increased compared with those in patients with chronic cervicitis（P 〈 0.05）, while those were downregulated when compared with patients with invasive cervical carcinoma（P 〈 0.05）.MVD, PSV and EDV in patients with cervical intraepithelial neoplasia （CIN） were upregulated comparedwith those in patients with chronic cervicitis （P 〈 0.05）, while those were decreased when compared with patients with invasive cervical carcinoma （P 〈 0.05）. However, RI decreased in patients with CIN whencompared with patients with chronic cervicitis （P 〈 0.05）, while that was increased when compared with patients with invasive cervical

关 键 词：宫颈癌 垂体瘤转化基因 血管内皮生长因子受体-3 肿瘤标志物 微血管密度 

分 类 号：R446.1[医药卫生—诊断学]