甲状腺相关眼病患者血清IL-17和IL-23的表达及临床意义  

Expression and clinical significance of IL-17 and IL-23 in serum of patients with thyroid-associated ophthalmopathy

作　　者：李红林[1] 刘艳秋[2] 郑绍同[3] 刘德珍[4] 周莉[4] 姚迪[4] 郑云会[3] 陆卫平[4] Hong-lin Li;Yan-qiu Liu;Shao-tong Zheng;De-zhen Liu;Li Zhou;Di Yao;Yun-hui Zheng;Wei-ping Lu(The Affiliated Huaian No.1 People＇s Hospital of Nanjing Medical University,Huaian,Jiangsu 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院生殖中心,江苏淮安223300 [2]南京医科大学附属淮安第一医院一分院检验科,江苏淮安223300 [3]南京医科大学附属淮安第一医院放免中心,江苏淮安223300 [4]南京医科大学附属淮安第一医院内分泌科,江苏淮安223300

出　　处：《中国现代医学杂志》2018年第30期105-108,共4页China Journal of Modern Medicine

摘　　要：目的探讨甲状腺相关眼病(TAO)患者血清中白细胞介素17(IL-17)、白细胞介素23(IL-23)的表达水平及其临床意义。方法选取2014年1月-2016月10月该院就诊的TAO患者46例,按临床活动度评分(CAS)将其分为TAO非活动期组(CAS<3)23例,TAO活动期组(CAS≥3)23例。另选22例健康体检者作为对照组(NC组)。采取ELISA法检测血清中IL-17与IL-23浓度,分析IL-17、IL-23浓度和CAS之间的相关性。结果 3组性别、年龄比较,差异无统计学意义(P>0.05)。TAO活动期组CAS评分高于TAO非活动期组(P<0.05);TAO活动期组和非活动期组血清IL-17水平分别为(1 268.21±215.03)和(983.52±207.14)pg/ml,均高于NC组(582.63±171.39)pg/ml(P<0.05),且TAO活动期组高于TAO非活动期组(P <0.05);TAO活动期组和非活动期组血清IL-23水平分别为(906.83±193.89)和(727.93±172.32)pg/ml,均高于NC组的(278.22±58.61)pg/ml(P<0.05),且TAO活动期高于TAO非活动期(P<0.05)。TAO患者的IL-17、IL-23水平与临床活动性评分(CAS)均呈正相关(r=0.6305和0.6892,均P=0.000)。结论 IL-17、IL-23在TAO患者外周血中均高表达。Objective To explore the levels of IL-17 and IL-23 in serum of patients with thyroid-associated ophthalmopathy （TAO） and their clinical significance. Methods Totally 46 TAO patients were enrolled in Huai＇an First People＇s Hospital from January 2014 to October 2016. According to the clinical activity score （CAS）, the patients were divided into inactive stage （CAS 〈 3, 23 patients） and active stage （CAS ≥ 3, 23 patients）. Exactly 22 healthy subjects were enrolled in normal control group （NC group）. Serum concentration of IL-17 and IL-23was detected by ELISA, and the correlations between IL-17, IL-23 and CAS were analyzed. Results There was no significant difference in gender and age among the 3 groups （P 〉 0.05）. The CAS score in TAO active group was significantly higher than that in TAO inactive group （P 〈 0.05）. The serum IL-17 levels were （1,268.21 ± 215.03） pg/ml and （983.52 ± 207.14） pg/ml in active stage and inactive stage of TAO patients, respectively; both of them were higher than that of NC group （582.63 ± 171.39） pg/ml （P 〈 0.05）, and that of TAO activity group was higher thanTAO inactive group （P 〈 0.05）. The serum IL-23 levels were （906.83 ± 193.89） pg/ml and （727.93 ± 172.32） pg/ml in active stage and inactive stage of patients, respectively; both of them were higher than that of NC group （278.22 ±58.61） pg/ml （P 〈 0.05）, and that of TAO activity group was higher than TAO inactive group （P 〈 0.05）. Levels of IL-17 and IL-23 in patients with TAO were positively correlated with clinical activity score （CAS） （r values were 0.6305and 0.6892, respectively）, and the correlation was statistically significant （P 〈 0.05）. Conclusion IL-17 and IL-23are highly expressed in the peripheral blood of patients with TAO; and they are positively correlated with CAS of TAO patients. IL-17 and IL-23 may be involved in the occurrence and development of TAO.

关 键 词：甲状腺相关眼病 白介素17 白介素23 IL-23/IL-17炎症轴 

分 类 号：R446.62[医药卫生—诊断学]