急性冠脉综合征关联生化标记物的研究进展  

Advances in Research on Biochemical Markers Associated with Acute Coronary Syndrome

作　　者：肖智谦[1] XIAO Zhi-qian(Department of Cardiovascular Medicine,Affiliated Hospital of Beihai Health School,Beihai 536100,Guangxi,Guangxi)

机构地区：[1]广西北海市卫生学校附属医院心血管内科,广西北海536100

出　　处：《医学信息》2018年第20期23-26,共4页Journal of Medical Information

基　　金：北海市科学研究与技术开发计划项目(编号:北科合20090210)

摘　　要：急性冠状动脉综合征是冠心病的一种严重类型,是以冠状动脉粥样硬化斑块破裂或侵袭,继发不同程度闭塞性血栓形成为病理基础的一组临床综合征,易损斑块、冠脉腔内血栓形成在ACS病程进展扮演重要角色。临床更迫切需要能在心肌损伤之前快速反映严重心肌缺血的标记物。本文旨在综述P选择素和超敏CRP等ACS关联生化标记物的研究进展,此类标记物因为与冠脉VP破裂和腔内血栓密切相关,引起血运的终止,导致恶性不良事件,所以能有助于方便快捷判断ACS预后和危险分层。随着检测技术改良,生化标记物更易于检测,我们应该联合检测多种指标,运用多种危险分层方法科学综合判断ACS危险性,才能正确指导ACS个体化诊治。Acute coronary syndrome is a serious type of coronary heart disease. It is a group of clinical syndrome,which is characterized by rupture or invasion of coronary atherosclerotic plaque and secondary occlusion thrombosis.lntracoronary thrombosis plays an important role in the progression of ACS.There is an urgent need for markers that can quickly reflect severe myocardial ischemia before myocardial injury.The purpose of this article is to review the research progress of P-selectin and hypersensitive CRP related biochemical markers of ACS.These markers are closely related to the rupture of coronary VP and intraluminal thrombus,which lead to the termination of blood circulation and lead to malignant adverse events.So it can help to judge the prognosis and risk stratification of ACS conveniently and quickly.With the improvement of detection technology and the easier detection of biochemical markers,we should jointly detect a variety of indicators and use a variety of risk stratification methods to scientifically and synthetically judge the risk of ACS in order to correctly guide the individualized diagnosis and treatment of ACS.

关 键 词：急性冠状动脉综合征 标记物 危险分层 

分 类 号：R541.4[医药卫生—心血管疾病]