探讨螺内酯对慢性心衰患者血浆脑钠肽水平及心功能的影响  

To Investigate the Effect of Spironolactone on Plasma Brain Natriuretic Peptide Level and Cardiac Function in Patients with Chronic Heart Failure

作　　者：王序[1] 彭志平[2] WANG Xu;PENG Zhi-ping(Baotou Mongolian Medicine and Chinese Medicine Hospital,Baotou,Inner Mongolia,014040;Baotou Central Hospital,Baotou,Inner Mongolia,014040)

机构地区：[1]内蒙古包头市蒙医中医医院,内蒙古包头014040 [2]内蒙古包头市中心医院,内蒙古包头014040

出　　处：《智慧健康》2018年第22期74-75,共2页Smart Healthcare

摘　　要：目的试论临床采用螺内酯对慢性心衰患者血浆脑钠肽水平及心功能的影响。方法随机抽选于2015年5月至2018年5月我院收治的180例慢性心衰患者,根据不同治疗方式分组。治疗组(n=90)应用螺内酯治疗;对照组(n=90)应用常规方式治疗。将两组的控制成效、临床指标参数变化进行评价与对比。结果治疗组的控制成效较对照组高(P<0.05);相比于对照组,治疗组的血清脑钠肽(BNP)、左心室射血分数(LVEF)、左心室舒张末期内径(LVEDd)均得到明显改善(P<0.05)。结论在临床治疗慢性心衰患者中应用螺内酯,疗效可观,可降低血浆脑钠肽水平,对改善患者心功能具有重大积极作用,有望成为今后治疗慢性心衰患者的首选方式。Objective To investigate the effect of spironolactone on plasma brain natriuretic peptide level and cardiac function in patients with chronic heart failure. Methods Random Ly selected 180 patients with chronic heart failure from May 2015 to May 2018 in our hospital. Groups were grouped according to different treatments. The treatment group（n =90） was treated with spironolactone, while the control group（n =90） received conventional treatment. Two groups of control effectiveness and clinical parameters were evaluated and compared. Results The control effect of the treatment group was higher than that of the control group（P〈 0.05）. Compared with the control group, the serum brain natriuretic peptide（BNP）, left ventricular ejection fraction（LVEF） and the left ventricular end diastolic diameter（LVEDd） in the treatment group were significantly improved（P〈 0.05）. Conclusion The use of spironolactone in clinical treatment of patients with chronic heart failure is effective, It is expected to become the first choice for patients with chronic heart failure in the future.

关 键 词：螺内酯 慢性心衰 血浆脑钠肽 

分 类 号：R541.6[医药卫生—心血管疾病]