地佐辛在创伤早期镇痛的临床研究  

Clinical study of Dezocine in the analgesia for early stage of trauma

作　　者：周先平[1] 邓川 杨敏[1] 沈川 周艳林 胡洲 徐琛 ZHOU Xian-ping;DENG Chuan;YANG Min(Department of Emergency Medicine,First Affiliated Hospital of Chongqing Medical University Qifiang Hospital,Qifiang 401420,China)

机构地区：[1]重庆医科大学附属第一医院綦江医院急诊医学科,401420 [2]不详

出　　处：《中国实用医药》2018年第27期19-21,共3页China Practical Medicine

基　　金：地佐辛在创伤早期镇痛的临床研究(项目编号:2016MSXM173)

摘　　要：目的探究地佐辛、曲马多在创伤早期镇痛中的应用效果及安全性。方法 200例创伤早期患者作为研究对象,随机分为实验组与对照组,各100例。两组患者均采用单盲给药。实验组给予地佐辛10 mg肌内注射,对照组给予曲马多100 mg肌内注射,观察比较两组患者治疗后15、30、60、120 min的视觉模拟评分法(VAS)评分、舒适度(BCS)评分、镇静(Ramsay)评分及不良反应发生情况。结果实验组治疗后15、30、60、120 min的VAS评分分别为(2.43±1.58)、(2.12±0.58)、(1.93±0.67)、(2.20±0.96)分,均明显低于对照组的(2.91±1.82)、(2.70±0.82)、(2.57±0.71)、(2.92±0.75)分,差异具有统计学意义(P<0.05);实验组治疗后15、30、60、120 min的BCS评分分别为(1.89±0.76)、(2.87±0.95)、(2.78±0.89)、(2.98±0.81)分,均明显高于对照组的(1.01±0.95)、(2.28±0.79)、(1.98±0.87)、(2.64±0.73)分,差异具有统计学意义(P<0.05);实验组治疗后15、30、60、120 min的Ramsay评分分别为(2.51±0.83)、(2.32±0.52)、(2.27±0.63)、(1.99±0.50)分,均明显高于对照组的(1.98±0.81)、(1.97±0.58)、(1.81±0.33)、(1.86±0.39)分,差异具有统计学意义(P<0.05);实验组不良反应发生率为7.00%,明显低于对照组的16.00%,差异具有统计学意义(P<0.05)。结论地佐辛早期镇痛效果显著,起效快、作用强、不良反应少,是一种理想的创伤早期镇痛药,值得临床推广应用。Objective To investigate the application effect and safety of Dezocine and Tramadol in the analgesia for early stage of trauma. Methods A total of 200 patients with early stage of trauma were selected as research objects, they were randomly divided into experimental group and control group, 100 cases in each group. Patients of the two groups were given single blind administration. The experimental group was given intramuscular injection of Dezocine 10 mg, the control group was given intramuscular injection of Tramadol 100 mg. The scores of visual analog scale（VAS）, Bruggrmann comfort scale（BCS）, Ramsay sedation scale after 15, 30, 60, 120 min of treatmnet and the occurrence of adverse reactions between the two groups were compared. Results The VAS scores of the experimental group after 15, 30, 60, 120 min of treatment were（2.43±1.58） scores,（2.12± 0.58） scores,（1.93±0.67） scores and（2.20±0.96） scores respectively, which were significantly lower than（2.91±1.82） scores,（2.70±0.82） scores,（2.57±0.71） scores and（2.92±0.75） scores of the control group, the differences were statistically significant（P〈0.05）. The BCS scores of the experimental group after 15, 30, 60, 120 min of treatment were（1.89±0.76） scores,（2.87±0.95） scores,（2.78±0.89） scores and（2.98±0.81） scores respectively, which were significantly higher than（1.01±0.95） scores,（2.28±0.79） scores,（1.98±0.87） scores and（2.64±0.73） scores of the control group, the differences were statistically significant（P〈0.05）. The scores of Ramsay sedation scale in the experimental group after 15, 30, 60, 120 min of treatment were（2.51±0.83） scores,（2.32±0.52） scores,（2.27±0.63） scores and（1.99±0.50） scores respectively, which were significantly higher than（1.98±0.81） scores,（1.97±0.58） scores,（1.81±0.33） scores and（1.86±0.39） scores in the control group, the differences were statistically significant（P〈0.05）. The incidence of adve

关 键 词：地佐辛 曲马多 创伤早期 镇痛 临床效果 

分 类 号：R641[医药卫生—外科学]