星点设计-效应面法优化山茱萸总环烯醚萜苷脂质体凝胶剂的制备工艺  

Preparation Process of Comus officinalis Total Iridoid Glycoside Liposomal Gel Optimized by the Central Composite Design-Response Surface Method

作　　者：苏艳莹[1] 雷小小 桂卉[1] SU Yanying, LEI Xiaoxiao, GUI Hui(Huncal Provincial Modernization Key Laboratory of Chinese Medicine, School of Pharmacy Huncal University of Chinese Medicine, Changsha, Hunan 410208, China)

机构地区：[1]湖南中医药大学药学院湖南省中药现代化研究重点实验室,湖南长沙410208

出　　处：《湖南中医药大学学报》2018年第11期1331-1335,共5页Journal of Hunan University of Chinese Medicine

基　　金：长沙市科学技术局基础研究项目(kq1701066)

摘　　要：目的优选山茱萸总环烯醚萜苷脂质体凝胶剂的制备工艺,并对其进行质量评价。方法以卡波姆-940用量、凝胶剂p H值、甘油用量为考察因素,以凝胶剂的外观、涂展性、均匀度、离心性的综合评价为指标,采用三因素三水平星点设计-效应面法优选脂质体凝胶剂的制备工艺。结果山茱萸总环烯醚萜苷脂质体凝胶剂的最佳制备工艺为卡波姆用量0.5%,pH值6.6,甘油用量15 g。根据优选的最佳工艺,平行制备3份凝胶剂,进行综合评分,综合评分结果分别为9.4、9.7、9.5。结论运用星点设计-效应面法优选出的山茱萸总环烯醚萜苷脂质体凝胶剂的制备工艺简单,方法可靠。Objective To optinfize the preparation process for Comus officiualis total iridoid glycoside liposomal gel, and to evaluate the quality of the gel. Methods With the amount of carbomer-940 used, pH value of the gel, and the amount of glycerol used as the factors for investigation and gel appearance, spreadability, uniformlity, and centrifugal property as evaluation indices, the three-factor three-level central composite design-response surface method was used to optimize the preparation process for liposomal gel. Results The optimal preparation process for Comus officinalis total iridoid glycoside liposomal gel was an amount of earbomer-940 used of 0.512%, a pH value of 6.6, and an amount of glycerol used of 15 g. Three samples of the gel were prepared using the optinml process and were then evaluated, and the comprehensive scores were 9.4, 9.7, and 9.5, respectively. Conclusion The preparation process for Comus officinalis total iridoid glycoside liposomal gel optimized by the central composite design- response surface method is simple and reliable.

关 键 词：星点设计-效应面法 山茱萸总环烯醚萜苷 纳求脂质体 凝胶剂 制备工艺 

分 类 号：R283.6[医药卫生—中药学]