哌拉西林他唑巴坦微泵与静脉滴注治疗下呼吸道感染的细菌学疗效及炎性指标对比  

Bacteriological Efficacy Between Micro-Pump and Intravenous Drip of Piperacillin/Tazobactam in the Treatment of Lower Respiratory Tract Infection and Their Effects on Inflammatory Markers

作　　者：赵光强 陈燕[1] 王彬[2] 梁桂林[2] Zhao Guangqiangl;Chen Yah;Wang Bin;Liang Guilin(Department of Respiratory Medicine,The Second Xiangya Hospital of Central South University,Changsha,Hunan,China 410000;Department of Respiratory Medicine,The People＇s Hospital of Sanya City,Sanya,Hainan,China 572000)

机构地区：[1]中南大学湘雅二医院呼吸内科,湖南长沙410000 [2]海南省三亚市人民医院呼吸内科,海南三亚572000

出　　处：《中国药业》2018年第21期61-63,共3页China Pharmaceuticals

摘　　要：目的对比哌拉西林他唑巴坦(PIPC/TAZ)微泵与传统静脉注射治疗下呼吸道感染的细菌学疗效及对炎性指标的影响。方法选取医院2014年9月至2017年10月收治的下呼吸道感染患者68例,根据给药方式的不同分为观察组和对照组,各34例。对照组患者给予PIPC/TAZ静脉滴注0. 5 h,观察组患者给予PIPC/TAZ微泵静脉输注3 h。结果观察组总有效率为91. 18%,明显高于对照组的73. 53%(χ~2=3. 943,P=0. 046);治疗后,两组患者血清炎性指标水平均较治疗前下降(P <0. 05),且观察组较对照组下降更明显(P <0. 05);观察组细菌清除率为91. 67%,明显高于对照组的73. 53%(χ~2=4. 050,P=0. 044);两组患者不良反应总发生率比较(11. 76%比8. 82%),差异无统计学意义(χ~2=0. 159,P=0. 690)。结论 PIPC/TAZ微泵静脉输注3 h治疗下呼吸道感染较传统静脉滴注细菌学疗效更显著,降低相关炎性指标水平作用更明显。Objective To compare the bacteriological efficacy between micro-pump and intravenous drip of piperacillin/tazobactam （PIPC/TAZ） in the treatment of lower respiratory tract infection and their effects on inflammatory markers. Methods Totally 68 patients with lower respiratory tract infection admitted to the hospital from September 2014 to October 2017 were selected and divided into the control group and the study group according to the different treatment methods, 34 cases in each group. The control group was given intravenous infusion of PIPC/TAZ for 0.5 h, while the observation group was given micro- pump intravenous infusion of PIPC/TAZ for 3 h. Results The total effective rate of the observation group was 91.18%, which was significantly higher than 73.53% of the control group（χ2 =3.943, P =0. 046）. After treatment, the levels of serum biochemical markers in the two groups were decreased than those before treatment（P 〈 0.05）, and the decrease in the observation group was more significant than that in the control group（P 〈 0.05）. The bacterial clearance rate of the observation group was 91.67%, which was significantly higher than 73.53% of the control group （χ2=4.050, P=0.044）.The total incidence rate of adverse reactions showed no significant difference between the two groups （11.76% vs. 8.82%, χ2 =0. 159, P=0. 690）. Conclusion Compared with the traditional intravenous drip of PIPC/TAZ in the treatment of lower respiratory tract infection, the micro- pump intravenous infusion of PIPC/TAZ for 3 h has the advantages of more significant bacteriological efficacy and plays better role in reducing the relevant inflammatory markers.

关 键 词：哌拉西林/他唑巴坦微泵 静脉滴注 下呼吸道感染 细菌学疗效 血清炎性指标 

分 类 号：R969.4[医药卫生—药理学] R978.11[医药卫生—药学]