普拉洛芬联合玻璃酸钠滴眼液治疗白内障超声乳化术后干眼疗效观察  

Clinical Observation on Praprofen Combined with Sodium Hyaluronate Eye Drops in the Treatment of Patients with Dry Eyes After Cataract Phacoemulsification

作　　者：范伟杰[1] 赵峰[1] Fan Weijie;Zhao Feng(Nanjing Hospital Affiliated to Nanjing Medical University,Nanjing First Hospital,Nanjing,Jiangsu,China 210006)

机构地区：[1]南京医科大学附属南京医院.南京市第一医院,江苏南京210006

出　　处：《中国药业》2018年第21期64-66,共3页China Pharmaceuticals

摘　　要：目的探讨普拉洛芬联合玻璃酸钠滴眼液治疗白内障超声乳化术后干眼的疗效。方法采用随机数字表法将白内障超声乳化术+人工晶体植入术后干眼患者92例(92眼)分为对照组和研究组,各46例。对照组给予玻璃酸钠滴眼液治疗,研究组在对照组基础上给予普拉洛芬滴眼液治疗。结果治疗后,两组泪膜破裂时间(BUT)、Schirmer试验与治疗前相比均显著升高(P <0. 05),且研究组与对照组同期相比均显著升高(P <0. 05);两组角膜荧光素染色与治疗前相比均显著降低(P <0. 05),且研究组与对照组同期相比均显著降低(P <0. 05);两组治疗2周、4周干眼症状评分与治疗前相比均显著降低(P <0. 05),且研究组与对照组同期相比均显著降低(P <0. 05);研究组临床总有效率高于对照组(91. 30%比76. 09%,P <0. 05);两组不良反应发生率相比差异不显著(10. 87%比8. 70%,P> 0. 05)。结论普拉洛芬联合玻璃酸钠滴眼液治疗白内障超声乳化术后干眼可延缓泪液蒸发,增加泪液分泌,改善干眼症状,安全性好,值得临床推广。Objective To investigate the clinical eft）ct of praprofen combined with Sodium Hyaluronate Eye Drops in the treatment of patients with dry eyes after cataract phacoemulsification. Methods Totally 92 patients（92 eyes） with dry eyes after cataract phacoemul- sification and intraocular lens implantation were divided into the control group and the study group by random number table method, 46 cases in each group. The control group was treated with Sodium Hyaluronate Eye Drops, while the study group was treated with Pralofen Eye Drops on the basis of the control group. Results After treatment, the tear break- up tmie（BUT）,Schirmer tests in the two groups were significantly better than those before treatment（ P 〈 0.05）, and those in the study group were significantly better than those in the control group in the same period（P 〈 0.05）. After treatment, the corneal fluorescein staining in the two groups was significantly lower than that before treatment（P 〈 0.05）, and that in the study group was significantly lower than that in the control group in the same period（ P 〈 0.05）. After 2,4 weeks of treatment, the dry eye symptom scores of the two groups were significantly lower than those before treatment（P 〈 0. 05）, and those in the study group were significantly lower than those in the control group in the same period （P 〈 0. 05）.The clinical eft）ctive rate of the study group was higher than that of the control group（91.30% vs. 76. 09%, P 〈 0. 05）. There was no significant dirt）fence in the incidence rate of adverse reaction between the two groups（10.87% vs. 8.70%, P 〉 0.05）. Conclusion Praprofen combined with Sodium Hyaluronate Eye Drops in the treatment of dry eyes after cataract phacoemulsification can delay the evaporation of tear, increase the secretion of tear and improve the symptoms of dry eye. It is safe and worthy of clinical promotion.

关 键 词：白内障 超声乳化术 干眼症 普拉洛芬滴眼液 玻璃酸钠滴眼液 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R988.1[医药卫生—药学]