阿戈美拉汀与艾司西酞普兰治疗伴失眠抑郁症对照研究  

Effect of Agomelatine or Escitalopram in the Treatment of Insomnia Complicated with Depression: a Control Study

作　　者：程雪[1] 杨辉[1] 黄雪萍[1] 周小艳[1] 文晏[1] 范征莉[1] 刘浩 邓永清[1] Cheng Xue;Yang Hui;Huang Xueping;Zhou Xiaoyan;Wen Yan;Fan Zhengli;Liu Hao;Deng Yongqing(Chongqing Mental Health Center,Chongqing,China 401147)

机构地区：[1]重庆市精神卫生中心,重庆401147

出　　处：《中国药业》2018年第21期70-73,共4页China Pharmaceuticals

摘　　要：目的比较阿戈美拉汀与艾司西酞普兰治疗伴有失眠抑郁症的疗效及安全性。方法将伴有失眠的抑郁症患者62例随机分为两组,分别给予阿戈美拉汀(观察组)和艾司西酞普兰(对照组),各31例,均治疗8周。结果治疗8周末,观察组与对照组临床痊愈率分别为41. 94%和38. 71%,有效率分别为67. 74%和64. 52%,两组比较无显著性差异(Z=-0. 193,P> 0. 05);重复测量方差分析显示,汉密尔顿抑郁量表(HAMD)、匹兹堡睡眠质量指数(PSQI)评分时间与分组之间均存在交互作用(F=8. 529,7. 617,P=0. 000);第1,2,4周末,观察组HAMD评分明显低于对照组(P <0. 05),但第8周末无显著性差异(P> 0. 05);观察组在第2,4,8周末PSQI总评分明显低于对照组(P <0. 05)。两组不良反应发生情况相似,均有较好耐受性。结论阿戈美拉汀治疗伴失眠抑郁症较艾司西酞普兰起效更快,抗抑郁及改善睡眠质量效果更强,耐受性好。Objective To compare the clinical effect and safety of agomelatine or escitalopram in the treatment of insomnia complicated with depression. Methods Totally 62 patients with insomnia complicated with depression were randomly divided into two groups, 31 eases in each group. The two groups were treated with agomelatine group（the observation group） and escitalopram group（the control group） for 8 weeks. Results After 8 weeks of treatment, the clinical cure rates of the observation group and the control group were 41.94% and 38.71%, the efi^ctive rates of the observation group and the control group were 67.74% and 64.51%, there was no significant difference between the two groups（Z = -0. 193, P 〉 0. 05）. Repeated measures analysis of variance showed that there was interaction between time and group in HAMD score and PSQI score（F= 8. 529, 7. 617, P =0. 000）. After 1, 2,4 weeks of treatment, the scores of HAMD in the observation group were significantly lower than those in the control group（P 〈 0.05）. However, there was no significant difference in the score of HAMD between the two groups at the end of the 8th week（P 〉 0.05）. After 2, 4, 8 weeks of treatment, the total scores of PSQI in the observation group were significantly lower than those in the control group（P 〈 0.05）. The adverse reactions were similar in two the groups and the tolerance of both groups was good. Conclusion Compared with escitalopram, agomelatine has better efficacy and took effect more quickly in the treatment of depression complicated with insomnia and it has better tolerabilky.

关 键 词：阿戈美拉汀 艾司西酞普兰 抑郁症 睡眠质量 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R971.3[医药卫生—药学]