百令胶囊对小儿糖尿病肾损伤患儿疗效研究  

Clinical effect of Bailing capsule in children with diabetic renal injury

作　　者：朱廷富 邹朝春[2] ZHU Tingfu1, ZOU Chaochun2(1 Department of Pediatrics, Hangzhouwan Hostipal, Ningbo 315000, Zhejiang, China ;2Department of Pediatrics, Children＇s Hostipal of Zhejiang University , Hangzhou 310003, Zhejiang , China)

机构地区：[1]宁波市杭州湾医院儿科 [2]浙江大学医学院附属儿童医院儿科

出　　处：《中国临床药理学与治疗学》2018年第8期912-915,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金："重大新药创制科技重大专项"化学新药质量标准研究与评价技术平台(2011ZX09303-001);浙江省医药卫生科技计划(2017KY158)

摘　　要：目的:评价百令胶囊对小儿糖尿病肾损伤患儿临床疗效研究。方法:48例糖尿病肾损伤患儿随机分为对照组和试验组,各24例。在常规治疗基础上,对照组给予胰岛素,0.5 U/kg,3次/d,皮下注射;试验组在对照组基础上加用百令胶囊,1.0 g/次,3次/d,口服。比较2组患儿治疗前后血清肌酐(SCr)、尿素氮(BUN)、β2微球蛋白(β2-MG)、骨成型蛋白7(BMP-7)水平、尿白蛋白排泄率(UAER)及治疗有效率。结果:治疗后,与对照组比较,试验组患儿血清SCr、BUN水平及UAER水平较低(P<0.05);试验组患儿血清β2-MG水平较低,血清BMP-7水平较高(P<0.05);试验组的治疗有效率(91.67%)显著高于对照组(70.83%)(P<0.05),其结果均有统计学意义。结论:百令胶囊能够显著降低糖尿病肾损伤患儿的血清β2-MG水平,提高血清BMP-7水平,改善肾功能,提高临床疗效。AIM： To evaluate the clinical effect of Bailing Capsule in children with diabetic renal injury. METHODS： Forty-eight cases of children with diabetic renal injury were randomly divided into control group and treatment group,24 cases in each group. On the basis of routine treatment,the control group was given insulin,0. 5 U/kg,3 times/d,subcutaneous injection; on the basis of the control group,the treatment group was treated with Bailing capsule,1. 0 g/time,3 times/d,oral. Serum creatinine（SCr）,blood urea nitrogen（BUN）,β2 microspheres（β2-MG）,bone morphogenetic protein 7（BMP-7） and urinary albumin excretion rate（UAER） levels,and efficiency of treatment were compared between groups before and after treatment.RESULTS： After treatment,compared with the control group,the serum levels of SCr,BUN and UAER were lower in the treatment group（P〈0.05）; the serum level of β2-MG was lower and the serum level of BMP-7 was higher in the treatment group（P〈0.05）; the treatment efficiency of the treatment group（91. 67%） was significantly higher than that of the control group（70. 83%）,the results were statistically significant. CONCLUSION： Bailing capsule can significantly reduce the serum level ofβ2-MG and improve the serum level of BMP-7 renal function and clinical efficacy in children with diabetic renal injury.

关 键 词：百令胶囊 糖尿病肾损伤 Β2微球蛋白 骨成型蛋白7 临床疗效 

分 类 号：R725.8[医药卫生—儿科]