Mett13-Mettl14 methyltransferase complex regulates the quiescence of adult hematopoietic stem cells  

作　　者：QiJason Yao Lina Sang Minghui Lin Xiujuan Yin Wenjie Dong Yuping Gong Bo O. Zhou 

机构地区：[1]State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, 200031 Shanghai, China [2]Department of Hematology, West China Hospital, Sichuan University, 610041 Sichuan, China

出　　处：《Cell Research》2018年第9期952-954,共3页细胞研究（英文版）

摘　　要：Dear Editor, N6-methyladenosine （m6A） is a common modification of mRNA that is catalyzed by the Mettl3-Mettll4 methyltransferase com- plex1, with WTAP as its regulatory subunit2. The physiological importance of m6A has been evidenced by its pivotal roles in tissue development and differentiation3-9. Hematopoietic stem cells （HSCs） are self-renewable multipotent progenitor cells that sustain all blood cell lineages throughout life. It has been well recognized that epigenetic modifications.

关 键 词：干细胞 造血 建筑群 静止 成年 调整 mRNA 织物开发 

分 类 号：Q813[生物学—生物工程] Q462