人类和啮齿类动物肺肿瘤比较  

Comparisons of human and rodent lung tumors

作　　者：邱波 王艳[2] 陈凯 孟广祯 张海静 王凤乾 胡建廷 QIU Bo1, WANG Yan2, CHEN Kai1, MENG Guangzhen1, ZHANG Haijing1, WANG Fengqian1, HU Jianting1(1. Shandong Pharmaceutical Academy, Shandong Provincial Key Laboratory of Chemical Drug, Jinan 250101, China ;2. Shan Dong Ying Cai University, Jinan 250104, China)

机构地区：[1]山东省药学科学院山东省化学药物重点实验室,山东济南250101 [2]山东英才学院,山东济南250104

出　　处：《药物评价研究》2018年第8期1369-1373,共5页Drug Evaluation Research

基　　金：山东抗体类和疫苗类生物药物临床前评价公共服务平台的完善与运行(2015CXPT00001)

摘　　要：肺癌是一种常见的肺部恶性肿瘤,近年来,由于吸烟和各种环境因素的影响,肺癌的发病率和病死率均迅速上升。啮齿类动物在肺癌的病因、有效致癌物、潜在协同效应、发病机制及新的肺癌诊断和治疗研究中起重要作用。从影响实验动物肺肿瘤反应的因素、人类和啮齿类动物肺肿瘤的形态学差异、肺癌的分子学改变方面进行综述,为肺肿瘤的临床前动物实验研究提供参考。Lung cancer is a common malignant tumor in the human population. In recent years, with the influence of smoking and various environmental factors, the incidence and mortality of lung cancer have risen rapidly in various countries. Laboratory animals play an important role in the etiology of lung cancer, effective concentrations of carcinogens, potential synergistic effects, identification of pathogenesis, and new diagnosis and treatment of lung cancer. This article only described the factors that affect the response of lung tumors in experimental animals, the morphological differences between lung tumors in humans and rodents, and the molecular changes in lung cancer, to provide references for preclinical animal experiments of lung tumors.

关 键 词：肺脏 肿瘤 啮齿类动物 大鼠 小鼠 人类 形态学 分子学 

分 类 号：R965.2[医药卫生—药理学]