芪苈强心胶囊联合参附注射液治疗慢支肺气肿合并休克的临床研究  

Effect of Qiliqiangxin capsule combined with Shenfu Injection in chronic bronchitis and emphysema patients with shock

作　　者：惠朋利 李英 HUI Pengli1, LI Ying2(1. Geriatric Department, Ankang Hospital of Traditional Chinese Medicine, Ankang 725000, China 2. Cardiology Department, Ankang Hospital of Traditional Chinese Medicine, Ankang 725000, China)

机构地区：[1]安康市中医院老年病科,陕西安康725000 [2]安康市中医院心内科,陕西安康725000

出　　处：《药物评价研究》2018年第8期1468-1472,共5页Drug Evaluation Research

摘　　要：目的探讨芪苈强心胶囊联合参附注射液治疗慢支肺气肿合并休克的价值。方法采用回顾性、随机、抽样研究方法,2014年7月—2017年1月选择在安康市中医院诊治的158例慢支肺气肿合并休克患者作为研究对象,根据治疗方法的不同分为观察组与对照组各79例,对照组给予参附注射液治疗,观察组在对照组治疗的基础上给予芪苈强心胶囊治疗,两组都治疗观察2周。结果观察组血压回升的时间显著少于对照组,差异有统计学意义(P<0.05);两组治疗1 h后血氧饱和度与1 h后心率对比无显著性差异。观察组的总有效率是98.7%,显著高于对照组的88.6%,差异有统计学意义(P<0.05)。两组治疗后的左心室射血分数(LVEF)均显著高于治疗前,同组治疗前后比较差异有统计学意义(P<0.05);且观察组显著高于对照组,差异有统计学意义(P<0.05)。两组治疗后血清B型利钠肽(BNP)水平均较治疗前降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组低于对照组,差异有统计学意义(P<0.05)。结论芪苈强心胶囊联合参附注射液治疗慢支肺气肿合并休克能改善心功能,降低血清BNP水平,从而提高治疗效果。Objective To investigate the effects of Qiliqiangxin capsule combined with Shenfu Injection in chronic bronchitis and emphysema patients with shock. Methods Used a retrospective, randomized sampling method, From July 2014 to January 2017, 158 chronic bronchitis and emphysema patients with shock in our hospital were selected as the research object and were divided into observation group and control group with 79 patients in each group accorded to the different treatment methods, the control group was given Shenfu injection treatment, the observation group were given Qiliqiangxin capsule based on the treatment in control group, two groups were treated for 2 weeks. Results The recovery time of blood pressure in the observation group was significantly lower than that in the control group（P〈0.05）. There were no significant difference in the blood oxygen saturation heart rate after 1 h treatment in the observation group compared with those of the control group. The total effective rates in the observation group and the control group were 98.7% and 88.6% respectively, and the observation group was significantly higher than that of the control group（P〈0.05）. The LVEF in the observation group and the control group after treatment was significantly higher than that before treatment（P〈0.05）, and the observation group was higher than that in the control group（P〈0.05）. The serum BNP level in the two groups were decreased after treatment（P〈0.05）, and the observation group was lower than that in the control group（P〈0.05）. Conclusion Qiliqiangxin capsule combined with Shenfu Injection in the treatment of chronic bronchitis and emphysema patients with shock can improve cardiac function and decrease the levels of BNP, so as to improve the therapeutic effect.

关 键 词：芪苈强心胶囊 参附注射液 慢支肺气肿 休克 心功能 

分 类 号：R969.4[医药卫生—药理学]