基于毒痰瘀虚理论的中草药复方治疗肝硬化的用药规律数据挖掘研究  

Study on the Data Mining of Prescription Rules of Chinese Medicine Compound in Treating Liver Cirrhosis Based on the Theory of Toxin, Phlegm, Blood Stasis and Deficiency

作　　者：吴辉坤[1,2] 李晓东[1,2] 谢丹 舒梓心 蔡岳 吴登[1] 江玉薇 鄢灯莹 Wu Huikun;Li Xiaodon;Xie Dan;Shu Zixin;Cai Yue;Wu Deng;Jiang Yuwei;Yan Dengying(Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan 430061,China;Hubei Province Academy of Traditional Chinese Medicine,Wuhan 430074,China;Clinical School of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Wuhan 430061,China)

机构地区：[1]湖北省中医院,武汉430061 [2]湖北省中医药研究院,武汉430074 [3]湖北中医药大学中医临床学院,武汉430061

出　　处：《世界科学技术-中医药现代化》2018年第6期983-989,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2012051):中医治疗慢性乙型肝炎真实世界效果比较研究;负责人:李晓东

摘　　要：目的:探讨从毒痰瘀虚治疗肝硬化的用药规律。方法:对肝硬化门诊患者的临床资料进行采集,通过数据集成与汇交后,对数据进行抽取、转换与加载,再利用数据分类、关联、聚类等数大数据分析方法对数据进行分析。结果:从毒痰瘀虚的用药规律显示,根据用药频次,解毒常用茵陈蒿、黄连、连翘、白花蛇舌草、黄芩,化痰常用薏苡仁、枳实、半夏、陈皮、瓜蒌,祛瘀常用丹参、郁金、莪术、泽兰、蒲黄,补虚常用茯苓、鳖甲、白术、黄芪、党参(太子参)。针对"毒"药的选择,主要为寒性、苦味,归肝胆脾胃经,针对"痰"药的选择,主要为温性、辛味,归脾经与肺经,针对"瘀"药的选择,主要为寒性、苦味,归肝经、心经与脾经,针对"虚"药的选择,主要为平性、甘味,归脾经、肝经与肾。结论:湖北省中医院中医肝病研究所采用中医药治疗肝硬化主要从毒痰瘀虚进行辨治。Objective： To explore the prescription rules in treating liver cirrhosis＇s based on poison phlegm blood stasis and deficiency. Method： Clinical data of patients, who had been diagnosed with liver cirrhosis, was gathered. The data had been extracted, transformed and loaded through data integration and remittance, then, the data was analyzed by data classification, association, clustering and other large data analysis methods. Results： The prescription rules based on poison phlegm blood stasis and deficiency showed that according to medication frequency, detoxification drugs commonly used ArtemisiacapillarisThunb, Coptis ehinensis Franch, Forsythia suspensa, Hedyotis diffusa Willd, and Scutellaria baicalensis Georgi, eliminating phlegm drugs commonly used Semen Coicis, Citrus aurantium L, Pinellia ternate, Pericarpium Citri Reticulatae and Trichosanthes kirilowii Maxim , removeing blood stasis drugs commonly used Radix Salviae Miltiorrhiae, Radix Curcumae, Rhizoma Curcumae, Herba Lycopi and Pollen Typhae , reinforcing deficiency drugs commonly used Poria, Carapax Trionycis, Rhizoma Atractylodis Macrocephalae, Radix Astragali seu Hedysari and Radix Codonopsis （Radix Pseudostellariae）. The selection of herbal medicine for poison in traditional Chinese medicine （TCM） is not only cold in property, bitter in flavor, but also converges to liver, gallbladder, spleen and stomach channel. The selection of herbal medicine for phlegm in TCM is not only warm in property, pungent in flavor, but also converges to spleen and lung channel. The selection of herbal medicine for blood stasis in TCM is not only cold in property, bitter in flavor, but also converges to liver, heart and spleen channel. The selection of herbal medicine for deficiency in TCM is not only mild in property, sweet in flavor, but also converges to spleen, liver and kidney channel. Conclusion： The syndrome differentiation and treatment of liver cirrhosis in Liver Institute of Hubei Provincial Hospital of Traditional Chinese are mainly based on

关 键 词：中医药 毒痰瘀虚 用药规律研究 数据挖掘 肝硬化 

分 类 号：R256.42[医药卫生—中医内科学]