中医药调控慢性萎缩性胃炎胃黏膜细胞凋亡的研究现状  

Research Status of Traditional Chinese Medicine Regulating Gastric Mucosal Apoptosis in Chronic Atrophic Gastritis

作　　者：李永乐 钱占红 郭志娟 孔令惠 杨巧芳 张锐[2] Li Yongle;Qian Zhanhong;Guo Zhijuan;Kong Linghui;Yang Qiaofang;Zhang Rui(College of Traditional Chinese Medicine,Inner Mongolia Medical University,Huhhot 010020,China;Inner Mongolia Medical University Affiliated People＇s Hospital,Huhhot 010010,China)

机构地区：[1]内蒙古医科大学中医学院,呼和浩特010020 [2]内蒙古医科大学附属人民医院,呼和浩特010010

出　　处：《世界科学技术-中医药现代化》2018年第6期1004-1009,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：内蒙古科技厅自然科学基金面上项目(2014MS0842):基于线粒体信号通路探究加味黄芪建中汤对慢性萎缩性胃炎大鼠胃黏膜细胞凋亡的调控机制;负责人:李永乐;内蒙古医科大学科技百万项目(YKD2017KJBW005):基于TRAIL通路探究加味黄芪建中汤对慢性萎缩性胃炎大鼠胃黏膜细胞增殖与凋亡失衡的影响及机制;负责人:李永乐;内蒙古医科大学人才团队自然科学项目(NYTD-2017006):内蒙古医科大学中医临床实训人才团队;负责人:李永乐;内蒙古医科大学科技百万(联合)重点项目(YKD2016KJBW(LH)025):SDF-1/CXCR4生物轴调控胃癌侵袭转移的分子机制研究;负责人:张锐

摘　　要：慢性萎缩性胃炎是临床消化系统的常见病、难治病,细胞凋亡是导致相关病理改变的重要原因。中医药作为临床防治消化系统疾病的重要手段之一,对慢性萎缩性胃炎中的作用以及机制成为近年来研究的重要方向。本文通过收集相关文献资料,在分析慢性萎缩性胃炎发病可能机制基础上,把握细胞凋亡这一关键环节,重点从线粒体途径、死亡受体途径、内质网途径及相关途径中具体信号通路阐明分析近年来中医药对慢性萎缩性胃炎胃黏膜细胞凋亡调控的研究现状,为进一步系统深入开展相关研究以及探索慢性萎缩性胃炎有效中医药治疗方案提供一定思路。Chronic atrophic gastritis （CAG） is a common and refractory disease of the digestive system in clinic. Apoptosis is the important reason which relates CAG pathological changes. As one of the important means of clinical prevention and treatment of digestive diseases, traditional Chinese medicine （TCM） in the role and mechanism of CAG related research has become an important direction in recent years. Based on the collection of related literatures and data, the paper analyzed the possible mechanism of CAG pathogenesis grasped the key aspect of apoptosis and clarified the research status of TCM on the regulation of gastric mucosal cell apoptosis in CAG in recent years through focusing on the specific si the above gnaling pathways in mitochondrial pathway, death receptor pathway, endoplasmic reticulum pathway. Through analysis, the paper provided some ideas for further systematic and in-depth research and explored CAG effective TCM program.

关 键 词：慢性萎缩性胃炎 细胞凋亡 中医药 调控 综述 

分 类 号：R259[医药卫生—中西医结合]