真实世界中神经根型颈椎病中成药使用分析  

Clinical Application of Chinese Patent Medicine Treating Cervical Radiculopathy in Real-world Study

作　　者：唐彬 魏戌[1] 高云 谢琪[4] 朱立国[1] 张兴平[1] 高经纬 银河[1] 蔡静怡[1] 董永丽[1] 王浩[1] Tang Bin;Wei Xu;Gao Yu;Xie Qi;Zhu Liguo;Zhang Xingping;Gao Jingwei;Yin He;Cai Jingyi;Dong Yongli;Wang Hao(Wangfing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;Belting University of Chinese Medicine,Beijing 100029,China;Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China;China Academy of Chinese Medical Sciences,Bering 100700,China)

机构地区：[1]中国中医科学院望京医院,北京100102 [2]北京中医药大学,北京100029 [3]中国中医科学院眼科医院,北京100040 [4]中国中医科学院,北京100700

出　　处：《世界科学技术-中医药现代化》2018年第6期1026-1031,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家中医药管理局中医药行业科研专项(201207001-04):全国中医医疗与临床科研信息共享的推广应用研究;负责人:高云;国家中医药管理局国家"十二五"科技支撑计划课题(2013BAI02B10):"病证结合"中医药真实世界临床科研方法学研究;负责人:谢琪;国家科技部中国中医科学院科技创新优势团队资助项目(YS1304):骨与关节退行性病变中医防治;负责人:朱立国

摘　　要：目的:分析临床实践中神经根型颈椎病(cervical radiculopathy,CR)中成药应用规律。方法:从2012年12月至2014年7月利用中医医疗与临床科研信息共享系统采集CR临床数据,研究对象为中国中医科学院望京医院就诊的628例CR住院与门诊患者。以使用中成药人群为研究对象,应用复杂网络liquorice软件计算中成药与西药、中成药与外用中药制剂应用的关联频度和互信息值,并绘制复杂网络图。结果:中成药使用例数分析,排在前两位的中成药为瘀血痹胶囊、颈舒颗粒。中成药与西药联合应用频次分析,颈舒颗粒与注射用腺苷钴胺联用频次最高,关联频度为822,互信息值为268.07。中成药与外用药物联合应用频次分析,痹祺胶囊与代温灸膏临床联用频次最高,关联频度为384,互信息值为1754.76。结论:进一步证实中成药治疗CR患者是以活血化瘀、通络止痛为基本治法。中西药联用、中药制剂内服外用联合在实践中应用广泛,联合用药的疗效、作用特点及安全性有待验证。Objective： Analyze the clinical application rule of Chinese patent medicine in cervical radiculopathy （CR）. Method： The clinical real-world data of CR were extracted by using information sharing system of traditional Chinese medicine and clinical research. Six hundred and twenty-eight inpatients and out patients with CR were enrolled from December 2012 to July 2014 in the information system database of Wangjing Hospital. The correlation analyses and mutual information value were recorded for Chinese patent medicine therapy application of all patients by using liquorice software. Complex network diagrams were generated. Result： Yuxuebi capsule and Jingshu granule is the highest frequency in application of Chinese patent medicine. Jingshu granule and Cobamamide for injection were the highest frequency in combined application of Chinese patent medicine and western medicine. Association frequency was 822, mutual information value was 268.07. Biqi capsule and Daiwenjiu cream were the highest frequency in combined application of Chinese patent medicine and topical drugs. Association frequency was 384, mutual information value was 1754.76. Conclusion： The basic treating principle for CR was promoting blood circulation and removing blood stasis. The efficacy and safety of combined Chinese patent medicine with other medicine need further research

关 键 词：神经根型颈椎病 真实世界 中成药 联合用药 复杂网络分析 

分 类 号：R33[医药卫生—人体生理学]