益生菌治疗哮喘的研究进展  

Probiotics in treating asthma:Research progress

作　　者：向熙 周龙甫[2] 周欣芸 李薇[2] 侯君[2] 肖雯靖 陈欣[1] 呼永河 XIANG Xi;ZHOU Longfu;ZHOU Xinyun;LI Wei;HOU Jun;XIAO Wenjing;CHEN Xin;HU Yonghe(School of Clinical Medicine,Southwest Jiaotong University,Chengdu,Sichuan 610083,China)

机构地区：[1]西南交通大学医学院,四川成都610083 [2]成都军区总医院,四川成都610083

出　　处：《中国微生态学杂志》2018年第9期1110-1113,F0003,共5页Chinese Journal of Microecology

基　　金：中国博士后科学基金面上项目(2016M603055);成都军区总医院医工联合专项基金(2016YHLH07)

摘　　要：哮喘是最常见的慢性气道炎症疾病,严重影响患者的生活质量,主要由体内Th1/Th2和Th17/Treg淋巴细胞亚群的失衡诱发。临床上治疗哮喘的药物主要为糖皮质激素、β2受体激动剂等,但这些药物只能缓解患者病情,无法达到根治目的,同时还会带来一定的副作用。益生菌是一类在适当的摄入数量时会对宿主机体带来益处的活体微生物,可通过多种途径调节机体的特异性免疫和非特异性免疫。益生菌可在肠道定植,通过肺―肠轴影响肺部的微生物菌群,从而影响肺部的免疫功能,对哮喘有一定的治疗作用,是治疗哮喘的潜在新药。本文综述了近年来益生菌治疗哮喘的研究进展。Asthma is the most common chronic inflammatory airway disease,and it seriously affects the quality of life of patients.It is mainly induced by the imbalance of Th1/Th2 and Th17/Treg lymphocyte subsets in the body.The drugs for clinical treatment of asthma are mainly glucocorticoids,β2 receptor agonists,etc.However,these drugs can only alleviate the patient′s condition rather than achieve the radical effect,meanwhile bring about certain side effects.Probiotics are a type of living microorganisms that will benefit the host organism at an appropriate intake by regulating the body′s specific immunity and non-specific immunity through multiple pathways.Probiotics can colonize the intestine and affect the microbial flora in the lungs through the gut-lung axis,thereby affecting the immune function of the lungs,thus have a certain therapeutic effect on asthma.It is a potential new drug for the treatment of asthma.This article reviews recent advances in the treatment of asthma with probiotics.

关 键 词：益生菌 免疫 哮喘 肺-肠轴 

分 类 号：R562.2[医药卫生—呼吸系统]