单纯疱疹病毒的医疗作用  

Medical effects of herpes simplex virus

作　　者：白媛媛[1] 郭洁[1] 李文静[1] BAI Yuan-yuan;GUO Jie;LI Wen-jing(Clinical Laboratory,Tianjin First Centeral Hospital,Tianjin 300192,China)

机构地区：[1]天津市第一中心医院检验科,天津300192

出　　处：《中国城乡企业卫生》2018年第10期33-35,共3页Chinese Journal of Urban and Rural Enterprise Hygiene

基　　金：天津市第一中心医院科技基金项目(院CM201811)

摘　　要：HSV-1和HSV-2是重要的人类病原体,此病毒系统性播散有致命危险。它可以引发各种疾患,从较轻微的皮肤病如口唇疱疹和生殖器疱疹到致命的脑炎及新生儿疱疹等。该病毒是人类发现的第一种也是被研究最多的病毒。对于其病毒复制及致病机理、基因表达及调节机制、影响宿主细胞及对宿主免疫系统侵袭方面已经有不少研究。这项研究使得单纯疱疹病毒发展成为治疗人类疾病的潜在剂型和媒介这一假设变为可能。这篇综述重点论述HSV基因产物的基本作用,回顾当今使用HSV突变体进行基因治疗的不同策略。由HSV衍生的载体包括:(1)基因传递扩增子载体;(2)复制缺陷性HSV重组疫苗;(3)用于溶瘤治疗的复制薄弱性HSV重组载体。HSV-1 and HSV-2 are important human causative agents with mortal danger of being spread systematically that can cause various kinds of diseases from slight skin disease such as oral herpes and genital herpes to deadly encephalitis and newborn herpes, etc. The virus was the first and most studied which ever been discovered. There are many researches for virus replication and pathogenesis, gene expression and regulatory mechanisms, how to affect host cells and how to invade the host immune system. This study makes it possible for HSV to develop into a potential dosage form and agent for treating human diseases. This review focus on the basic role of HSV gene products and review the different strategies of gene therapy in using HSV mutants. The vectors derived from HSV include：（1）gene transfer amplification vector;（2）duplication defect HSV recombinant vaccines;（3）weak HSV recombinant vector for oncolytic therapy.

关 键 词：单纯疱疹病毒 基因 药物 

分 类 号：R459.9[医药卫生—治疗学]