不同剂量HCG对体外受精-胚胎移植中卵巢正常反应者妊娠结局的影响  

Effect of HCG at different dosages on the pregnancy outcomes in the patients with normal ovarian response of IVF-ET

作　　者：张帆 ZHANG Fan(Reproductive Medicine Center,Liuzhou Women and Children Health Care Hospital,Liuzhou 545001,China)

机构地区：[1]广西柳州市妇幼保健院生殖助孕中心,广西柳州545001

出　　处：《中国优生与遗传杂志》2018年第9期114-115,52,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的研究不同剂量人绒毛膜促性腺激素(HCG)对体外受精-胚胎移植中卵巢正常反应患者卵子成熟及妊娠结局的影响。方法回顾性分析210个体外受精/卵胞浆内单精子注射-胚胎移植(IVF/ICSI-ET)周期,按肌注HCG剂量不同分为4000IU组,6000 IU组,10000IU组,统计观察3组患者获卵数,获卵率,成熟卵子率,受精率,临床妊娠率,流产率,卵巢过度刺激综合征(OHSS)发生率是否存在差异。结果 (1)3组患者年龄,不孕年限,体重指数,基础FSH,LH,E2,促性腺激素(Gn)总量,HCG日LH,HCG日E2差异均无统计学意义(P>0.05)。(2)3组患者获卵数,获卵率,成熟卵子率,受精率,临床妊娠率,流产率,OHSS发生率差异均无统计学意义(P>0.05),但HCG4000 IU组患者OHSS发生率有降低趋势。结论在卵巢正常反应患者中,适当减少HCG的注射剂量不影响卵子成熟及妊娠结局且OHSS发生率有降低趋势。Objective：To study the effects of different doses of HCG on egg maturation and pregnancy Outcomes in the patients with normal ovarian response of IVF-ET. Methods：A retrospective analysis of 210 IVF/ICSI-ET cycles,by intramuscular injection of HCG dose into group of 4000 IU,group of 6000 IU,group of10000 IU,and the number of egg retrieval,egg retrieval rate,egg maturation rate,fertilization rate,pregnancy rate,abortion rate,OHSS occurred rate of three groups were observed. Results：The difference between three groups of patients age,infertile time,body mass index,basal FSH value,basal LH value,basal E2 value,total dosags of Gn,LH value,E2 value on the day of injection HCG were not statistically significant（P〉0.05）. The difference between three groups of the number of egg retrieval,egg retrieval rate,egg maturation rate,fertilization rate,pregnancy rate,abortion rate,OHSS occurred rate were not statistically significant（P〉0.05）,but the OHSS occurred rate of group 4000 IU is lowest in three groups. Conclusion：The decreasing dosage of HCG for ovulation induction has no negative influence for egg maturation and pregnancy Outcomes in the patients with normal ovarian response of IVF-ET,and the OHSS occurred rate is lower.

关 键 词：体外受精-胚胎移植 人绒毛膜促性腺激素 卵巢过度刺激综合征 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]