单纯疱疹病毒感染与老年人心房颤动的相关性研究  

Association between herpes simplex virus infection and atrial fibrillation in elderly individuals

作　　者：刘念[1] 刘少伟[1] 李林凌 赵倩倩 闻松男[1] 阮燕菲[1] 李新[1] 李松南[1] 龙德勇[1] 汤日波[1] 喻荣辉[1] 杜昕[1] 董建增[1] 马长生[1] Liu Nian , Liu Shaowei , Li Linling , Zhao Qianqian , Wen Songnan , Ruan Yanfei , Li Xin , Li Songnan , Long Deyong , Tang Ribo ,Yu Ronghui ,Du Xin ,Dong Jianzeng ,Ma Changsheng(Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029 , China)

机构地区：[1]首都医科大学附属北京安贞医院心内科,100029

出　　处：《中华老年医学杂志》2018年第10期1078-1081,共4页Chinese Journal of Geriatrics

基　　金：国家自然科学基金（81530016、81670291、81770318）

摘　　要：目的探讨单纯疱疹病毒（HSV）感染与老年人高敏C反应蛋白（hsCRP）水平升高及心房颤动（房颤）的相关。方法回顾性筛选2603例连续年龄≥60岁房颤患者，排除有器质性心脏病和已知房颤危险因素的患者，最终49例纳人数据分析；对照组为中国心律失常登记研究的55例老年人。分析临床基线特征，检测单纯疱疹病毒（HSV）-1和HSV-2抗体及hsCRP水平。结果房颤患者与对照组比较，HSV-1（314．5±63．6）mg／L比（216．0±50．7）mg／L和HSV-2（400．1±57．2）mg／L比（306．3±64．5）mg／L，抗体水平升高（P〈0．01）。线性回归分析结果显示，血浆hsCRP水平与HSV1和HSV-2抗体呈正相关（r值分别为0．291、0．188，均P〈0．01）。多因素回归分析，HSV1和HSV2抗体水平与房颤发生相关（OR值分别为1．035、1．034，均P〈0．01）。抗HSV-1为284．96mg／L预测房颤发生率的敏感性为67．3％，特异性为92．7％；抗HSV-2为366．26mg／L抗体预测的敏感性为67．3％，特异性为85．5％。结论血浆HSV-1抗体和HSV-2抗体升高与老年人房颤的发生相关。Objective To investigate associations of herpes simplex virus（HSV）infection with elevated high-sensitivity C-reactive protein（hsCRP）level and the development of atrial fibrillation（AF） in elderly individuals. Methods Through screening a total of 2,603 individuals,49 patients aged 60 years or over with AF and without structural heart diseases and known risk factors for AF were selected for data collection. Fifty-five elderly healthy control subjects were selected from a populationbased Chinese Arrhythmia Registry. Baseline characteristics, plasma antibody levels against HSV 1 and 2, and level of hsCRP were analyzed. Results Level of antibodies against HSV-1 was significantly higher in AF patients[（314.5±63.6）mg/L than in control subjects（216.0±50.7） mg/L, P〈0. 01].Level of antibodies against HSV-2 was significantly higher in AF patients[（400.1±50.7） mg/L than in control subjects （ 306.3 ± 64. 5 ） mg/L, P 〈 0.01 ] . Linear regression analysis demonstrated a positive correlation of plasma levels of hsCRP with both anti-HSV-1 and anti-HSV-2 IgG antibodies（r= 0. 291,0. 188, all P〈0.01）. In multiple logistic regression analysis, HSV-1 and HSV-2 antibody levels were significantly associated with AF occurrence（OR = 1. 035 and 1. 034 ,all P 〈0.01）. The optimal cut-off point for predicting AF occurrence was 284.96 mg/L for anti-HSV-1 with sensitivity of 67.3% and a specificity of 92.7% ,and was 366.26 mg/L for anti-HSV-2 with a sensitivity of 67.3 % and a specificity of 85.5% , respectively. Conclusions The increased plasma levels of anti HSV 1 and anti-HSV-2 antibodies are significantly associated with AF occurrence in elderly adults.

关 键 词：心房颤动 单纯疱疹病毒属 C反应蛋白质 

分 类 号：R541.75[医药卫生—心血管疾病] R752.11[医药卫生—内科学]