α-硫辛酸用于2型糖尿病周围神经病变患者的临床疗效  

Analysis of the clinical efficacy of DL-thioctic acid on type 2 diabetes peripheral neuropathy

作　　者：杨雨平[1] 林东源[1] 叶健波[1] 林华征[1] 杨吉 YANG Yuping;LIN Dongyuan;YE Jianbo;LIN Huazheng;YANG Ji(Department of Endocrinology,Guigang People＇s Hospital,Guigang 537100,Guangxi,China;Department of Endocrinology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]贵港市人民医院内分泌科,广西贵港537100 [2]广西医科大学第一附属医院内分泌科,广西南宁530021

出　　处：《西部医学》2018年第10期1456-1461,共6页Medical Journal of West China

基　　金：广西自然科学基金(0832184)

摘　　要：目的探讨α-硫辛酸用于2型糖尿病周围神经病变患者的临床疗效。方法选择2014年6月～2016年11月在我院接受治疗的2型糖尿病周围神经病变患者124例,根据治疗方法不同分为观察组和对照组,对照组采用常规治疗,观察组在此基础上加用α-硫辛酸治疗。观察两组患者治疗后临床疗效,并在治疗前后对所有患者进行TSS评分,分析两组患者治疗前后运动神经传导速度、感觉神经传导速度,血清Apo-a、sVCAM-1、8-ISO-PGF2α水平以及血压、血脂、血糖水平变化。结果治疗后观察组临床疗效与对照组相比差异有统计学意义(P<0.05);与治疗前相比,两组患者的神经传导速度与血清Apo-a水平较高,TSS评分与血清sVCAM-1、8-ISO-PGF2α水平较低(P<0.05);观察组患者神经传导速度、血清Apo-a水平较高,TSS评分与血清sVCAM-1、8-ISO-PGF2α水平较低,与对照组比较差异有统计学意义(P<0.05);两组患者血压、血糖水平较治疗前比较,差异均无统计学意义(P>0.05);治疗后观察组总胆固醇水平明显降低,与对照组比较差异有统计学意义(P<0.05)。结论α-硫辛酸可通过降低氧化应激、调节代谢紊乱、改善血管内皮炎症损伤等多重机制,降低2型糖尿病周围神经病变患者血清sVCAM-1、8-ISO-PGF2α水平,增加血清Apo-a水平,改善患者临床症状以及神经传导速度,可显著提高治疗疗效。Objective To study clinical efficacy of DL-thioctic acid on Type 2 diabetes peripheral neuropathy.Methods 124 patients of Type 2 diabetes peripheral neuropathy from June 2014 to November 2016 in our hospital were divided into observation group and control group.The control group was treated with routine treatment,while the observation group was treated with DL-thioctic acid.The clinical efficacy and TSS scores of all patients before and after treatment were observed.The nerve conduction velocity before and after the treatment,sensory nerve conduction velocity and Apo-a,sVCAM-1,8-ISO-PGF2α,blood pressure,blood lipid,blood sugar level changes were observed.Results The clinical curative effect of observation group was obviously higher than that of control group（P〈0.05）.The nerve conduction speed and serum apo-a of the two groups after treatment were higher than that before treatment.TSS score and serum sVCAM-1 and 8-iso-PGF2α of the two groups after treatment were lower than that before treatment（P〈0.05）.The nerve conduction speed and serum Apo-a of the observation group were higher than that of control group.TSS score,serum sVCAM-1 and 8-iso-PGF2α of the observation group were lower than that of control group（P〈0.05）.Before and after treatment,the blood pressure and blood glucose levels in both groups were significantly different（P〉0.05）.The total cholesterol levels were significantly reduced after the treatment group（P〈0.05）.Conclusion DL-thioctic acid can reduce oxidative stress and fade disorder,improve endothelial inflammatory lesions,reduce serum sVCAM-1 and 8-iso-PGF2α level and improve the clinical symptoms and nerve conduction speed of patients with peripheral neuropathy of type 2 diabetes.

关 键 词：Α-硫辛酸 2型糖尿病周围神经病变 疗效 

分 类 号：R587.1[医药卫生—内分泌]