冠心病痰瘀互结证一般情况与生化指标相关性分析研究  

Correlation Analysis Between General Condition and Biochemical Indexes of Coronary Heart Disease with Phlegm and Blood Stasis Syndrome

作　　者：王朔[1] 蔡雪朦 邓兵[2] 毛美娇[2] 杜廷海[3] 李彬[3] 杨宝平[4] 于研 张虹[5] 张世姝[5] 毛静远[6] 王贤良[6] 徐强[7] 张蕾 宋光明[8] 田莉 边育红[1] 王丽[9] 闫丹丹 高杉[1] 李琳[1] 高树明[1] 潘晔[1] 胡镜清[10] 徐一兰[1] 于春泉[1] WANG Shuo;CAI Xue-meng;DENG Bing;MAO Mei-jiao;DU Ting-hai;LI Bin;YANG Bao-ping;YU Yan;ZHANG Hong;ZHANG Sbi-shu;MAO Jing-yuan;WANG Xian-liang;XU Qiang;ZHANG Lei;SONG Guang-ming;TIAN LI;BIAN Yu-hong;WANG Li;YAN Dan-dan;GAO Shan;LI Lin;GAO Shu-ming;PAN Ye;HU Jing-qing;XU Yi-lanl;YU Chun-quan(Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Longhua Hospital Affiliated Shanghai university of Traditional Chinese Medicine,Shanghai 200032,China;The first Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 136300,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730699,China;Tianjin Nankai Hospital,Tianjin 300100,China;First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300150,China;Tianjin Wuqing District Hospital of Chinese Medicine,Tianjin 301700,China;Tianfin Second People＇s Hospital,Tianfin 300192,China;Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing,100700,China)

机构地区：[1]天津中医药大学,天津300193 [2]上海中医药大学附属龙华医院,上海200032 [3]河南中医药大学第一附属医院,郑州136300 [4]甘肃省中医院,兰州730699 [5]天津市南开医院,天津300100 [6]天津中医药大学第一附属医院,天津300193 [7]天津中医药大学第二附属医院,天津300150 [8]天津市武清区中医医院,天津301700 [9]天津市第二人民医院,天津300192 [10]中国中医科学院中医基础理论研究所,北京100700

出　　处：《中国中医基础医学杂志》2018年第9期1249-1252,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：国家重点基础研究计划(973计划)项目(2014CB542902)-冠心病痰瘀互结证病证方对应关系的临床研究

摘　　要：目的:探讨冠心病稳定型心绞痛痰瘀互结证患者一般情况与生化指标间的相关性。方法:从全国7家临床研究中心共入组受试者83例,脱失6例,最终纳入受试者77例,其中冠心病痰瘀互结证患者38例,气阴两虚证患者39例。采用多中心、小样本、精细化的临床研究方法,调查2组患者一般情况及生化指标,并做聚类分析、主成分分析。结果:对冠心病痰瘀互结证患者一般情况与生化指标作主成分分析及聚类分析,结果显示冠心病痰瘀互结证患者肥胖程度、职业、血压与炎症反应关系密切,病程、合并疾病、合并用药与凝血功能、脂代谢方面关系密切。结论:痰瘀互结证患者在上述一般情况与炎症因子、脂代谢相关因子、凝血功能方面存在一定联系,应注重指标间的交互影响与变化,对于临床中医证候的诊断尤其是冠心病指征的辨识及患者病情改变具有重要的参考意义。Objective： To investigate the correlation between general conditions and biochemical markers in patients with phlegm and blood stasis syndrome of CHD. Methods： Eighty-three subjects were enrolled in seven clinical research centers across the country. Six patients were lost. Seventy-seven subjects were included in the study,including 38 patients with phlegm and blood stasis syndrome of CHD and 39 patients with qi-yin deficiency syndrome. The method which is multicenter,small-sample,precision was used to investigate the general conditions and biochemical indicators of the 2 groups of subjects. Cluster analysis and principal component analysis were performed on general conditions and biochemical indicators. Results： The results showed that the degree of fattness,jobs,blood pressure are related with some inflamatory markers. The course of disease,the combined diseases and combined drugs are related with coagulation function and lipid metabolism. Conclusion： Changes in above factors should be paid more attention which include patient general condition,inflamatory markers,lipid metabolism markers,coagulation function markers. These factors have important reference significance for the diagnosis of clinical syndromes of TCM,especially the identification of CHDindications,and changes in patients＇ conditions.

关 键 词：冠心病 痰瘀互结 一般情况 生化指标 相关性分析 

分 类 号：R541.4[医药卫生—心血管疾病]