右美托咪定对人离体妊娠子宫平滑肌自发性收缩的影响  

Effect of dexmedetomidine isolated human pregnant uterine muscles

作　　者：李平 吕胜 罗林丽 高兴蓉 黄蔚 LI Ping;L YU Sheng;LUO Linli;GAO Xingrong;HUANG Wei(Department of Anesthesiology,West China Second University Hospi-tal,Sichuan University ~ Key Laboratory of Birth Defects and Related Diseases of Women and Chil-dren（Sichuan University）,Ministry of Education,Chengdu 610041,China)

机构地区：[1]四川大学华西第二医院麻醉科出生缺陷与相关妇儿疾病教育部重点实验室,成都市610041

出　　处：《临床麻醉学杂志》2018年第9期895-898,共4页Journal of Clinical Anesthesiology

基　　金：四川大学新芽基金(kx030)

摘　　要：目的研究不同浓度右美托咪定对人离体子宫平滑肌自发性收缩的影响。方法已经发生自主规律收缩的人妊娠子宫平滑肌60例。随机分为对照组和右美托咪定组,每组30例。对照组每次给予相同容量Krebs液,右美托咪定组采用累积给药法使右美托咪定溶液浓度达到1×10^(-8)、3×10^(-8)、1×10^(-7)、3×10^(-7)、1×10^(-6)、3×10^(-6)、1×10^(-5) mol/L,应用BL-420F生物信号采集处理系统记录不同浓度下子宫平滑肌的收缩强度、收缩频率及收缩持续时间。结果与对照组比较,右美托咪定浓度为1×10~(-8、3×10~(-8、1×10^(-7) mol/L时对人离体子宫平滑肌收缩强度、收缩频率和持续时间差异均无统计学意义,右美托咪定浓度为1×10^(-6)、3×10^(-6)和1×10^(-5) mol/L时人离体子宫平滑肌的收缩强度明显减弱、收缩持续时间和频率明显延长(P<0.05)。结论低浓度右美托咪定对子宫平滑肌的收缩无影响,高浓度(大于1×10^(-6) mol/L)右美托咪定以剂量依赖的方式抑制人离体妊娠子宫平滑肌的收缩。Objective To investigate the effects of dexmedetomidine on spontaneous contractions of isolated human pregnant myometrial smooth muscles.Methods Sixty isolated human pregnant myometrial muscle strips with rhythmic spontaneous contraction were randomly divided into two groups,experimental group（n = 30）and control group（n = 30）.In experimental group,dexmedetomidine was added cumulatively（1×10^（-8）,3×10^（-8）,1×10^（-7）,3×10^（-7）,1×10^（-6）,3×10^（-6）,1×10^（-5） mol/L）,while the control group was given same dose of Krebs solution.The amplitude,frequency and duration of uterine contraction were monitored by BL-420 F biosignal system.Results Compared with the control group,low concentration（1×10^（-8）,3×10^（-8）,1×10^（-7） mol/L）of dexmedetomidine had no significant effect on uterine contraction,however,high doses of dexmedetomidine（1×10^（-6）,3×10^（-6）,1×10^（-5） mol/L）decreased contractive amplitude,extended the frequency and duration of contraction.Conclusion Dexmedetomidine at concentrations of 10^（-6）,3×10^（-6） and 10^（-5） mol/L has a dose-depended inhibitory effects on the contraction of isolated human pregnant myometrial smooth muscles.

关 键 词：右美托咪定 子宫平滑肌 收缩 妊娠 

分 类 号：R614[医药卫生—麻醉学]