Jumonji domain-containing protein family： the functions beyond lysine demethylation  

作　　者：Yuan Meng Hongzhi Li Changwei Liu Li Zheng Binghui Shen 

机构地区：[1]Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA [2]Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA

出　　处：《Journal of Molecular Cell Biology》2018年第4期371-373,共3页分子细胞生物学报（英文版）

摘　　要：Two of the unsolved but important questions in epigenetics are whether arginine demethylases （RDMs） exist and whether proteolytic cleavage of the histone tails and subsequent histone remodeling are a major epigenetic modification process. Jumonji domain （JmjC）-containing proteins have been characterized as lysine demethylases （KDMs） in a certain degree （Klose et al., 2006）. Emerging evidences indicate that they also catalyze demethylation reaction on the arginine residues and proteolytic removal of histone tails. These processes are likely associated with biological meanings.

关 键 词：精氨酸 蛋白质 包含域 家庭 尾巴 生物 

分 类 号：Q517[生物学—生物化学] Q51