胺碘酮联合阿托伐他汀对非缺血性心力衰竭伴恶性心律失常的疗效及炎性因子的影响分析  

Effect of amiodarone combined with atorvastatin on non-ischemic heart failure with malignant arrhythmia and its influence on inflammatory factors

作　　者：徐高峰 XU Gaofeng(Fengxian District Central Hospital of Shanghai City, Shanghai 201499, China)

机构地区：[1]上海市奉贤区中心医院,上海201499

出　　处：《中国医药科学》2018年第18期56-59,共4页China Medicine And Pharmacy

摘　　要：目的观察胺碘酮联合阿托伐他汀对非缺血性心衰伴恶性心律失常的疗效及炎性因子的影响效果,探讨有效的治疗措施。方法选择我科2015年2月～2017年2月收治的64例非缺血性心力衰竭及恶性心律失常患者,根据随机数字表法分为两组,即予以胺碘酮联合阿托伐他汀归为观察组,予以胺碘酮者归为对照组,每组均32例,观察两组患者疗效,血清炎症因子水平(TNF-α、IL-6、hs-CRP)、生活质量(HPLPⅡ量表)以及随访半年观察预后情况。结果与对照组比较,观察组有效率90.62%,随访半年,室性阵发性心动过速、心功能恶化、死亡均为1例(3.12%),以及TNF-α、IL-6、hs-CRP水平均降低明显,人际间关系、营养/健康责任、以及总分均增加明显,差异有统计学意义(P <0.05),组内比较,治疗后两组患者的TNF-α、IL-6、hs-CRP水平均较治疗前降低明显,差异有统计学意义(P <0.05)。结论胺碘酮与阿托伐他汀联用用药,可较好的改善非缺血性心衰伴恶性心律失常患者的血清炎症因子TNF-α、IL-6、hs-CRP水平,提高疗效及生活质量,对于预后效果较好。Objective To observe curative effect of amiodarone combined with atorvastatin on non-ischemic heart failure with malignant arrhythmia and its influence on inflammatory factors, in further to explore the effective treatment measures. Methods Sixty-four patients with non-ischemic heart failure and malignant arrhythmia admitted to our department from February 2015 to February 2017 were selected as research objects and divided into two groups according to random digital table method. The observation group was given amiodarone combined with atorvastatin, while the control group was given amiodarone, 32 cases in each group. The curative effect, serum inflammatory factor level（TNF-α, IL-6, hs- CRP）, life quality（HPLP Ⅱ scale） and prognosis situation after half a year＇s follow up of two groups were observed. Results Compared with control group, the effective percentage of observation group was 90.62%, follow up half year, ventricular paroxysmal tachycardia, cardiac function deterioration and death all was just 1 case（3.12%）, the level of TNF-a, IL-6, hs-CRP all decreased obviously, interpersonal relationship, nutrition/health responsibility, and total score all increased obviously, The difference was statistically significant （P 〈 0.05）. After treatment, the levels of TNF-α, IL-6 and hs-CRP in the two groups were significantly lower than those before treatment（P 〈 0.05）. Conclusion Amiodarone combined with atorvastatin can improve the levels of serum inflammatory factors（TNF-α, IL-6 and hs-CRP） in patients with non-ischemic heart failure and malignant arrhythmia, improve curative effect and life quality, relative better to prognostic effect.

关 键 词：非缺血性心衰 恶性心律失常 胺碘酮 阿托伐他汀 疗效 炎症因子 

分 类 号：R541[医药卫生—心血管疾病]