未进行抗病毒治疗的艾滋病患者血常规指标与CD4^＋T细胞计数的相关性研究  

Correlation between blood routine indicators and CD4 T cell count in AIDS patients without antiviral therapy

作　　者：薛黎坚[1] 王文明[1] 陈权[1] 姚庆完[1] 唐琴芳[1] Xue Lijian;Wang Wenming;Chen Quan;Yao Qingwan;Tang Qinfang(Kunshan Center for Disease Prevention and Control,Kunshan,Jiangsu 215300,China)

机构地区：[1]昆山市疾病预防控制中心性艾科,江苏省昆山215300

出　　处：《中国基层医药》2018年第17期2244-2248,I0005,共6页Chinese Journal of Primary Medicine and Pharmacy

基　　金：江苏省苏州市“科教兴卫”青年科技项目（KJXW2016064）

摘　　要：目的研究未进行抗病毒治疗的艾滋病患者血常规各项检测指标与c04T、co；T淋巴细胞的相关性，寻求普及性好、廉价、有效的艾滋病病程的监测指标。方法收集2013年8月至2016年12月昆山市疾病预防控制中心随访管理的经艾滋病实验室检测确认的艾滋病感染者或患者，应用回归分析等统计学方法对333名未进行抗病毒治疗的艾滋病患者血样白细胞（WBC）、淋巴细胞计数（W-SCC）等指标与CDfT、cDfT淋巴细胞数的相关性进行分析和研究。结果333名艾滋病患者血常规指标异常率较高，主要检测指标均在参考值范围内的仅占30．63％。女性艾滋病感染者晚发现比例高于男性。艾滋病患者血中WBC、W-SCC、W-LCC、RBC、HGB、PLT指标与CD4＋T淋巴细胞的相关关系均有统计学意义，相关系数分别为0．408、0．541、0．157、0．337、0．338、0．166。用W-SCC（X）估算CD4＋淋巴细胞计数（Y）的方程为Y=120．913x＋90．339。结论未进行抗病毒治疗的艾滋病患者淋巴细胞计数指标与CD4＋T淋巴细胞具有较强的相关性，可以将其作为艾滋病患者机体免疫状况的一个重要指标。同时，应加强预防艾滋病大众宣传，促进艾滋病早发现、早治疗，提高艾滋病患者生存质量。Objective To study the correlation between the blood routine indicators and CD4＋ T, CDs T lymphocytes in AIDS patients without antiviral treatment,and to find a simple, cheap and effective monitoring indicator. Methods A study of 333 AIDS patients without antiviral treatment was performed. The methods of regression analysis and other statistical methods were applied to research the correlation between WBC, W - SCC and CD4 ＋T, CD8＋ T cell count among HIV/AIDS. Results The rate of routine blood abnormalities among 333 HIV/AIDS patients was very high, the main test indicators within the reference range only accounted for 30.63%. The proportion of late diagnosis infected with HIV among women was higher than that of males. Significant correlations were observed between CD4＋ Tcel] count and WBC,W- SCC,W- LCC,RBC,HGB,PLT（r =0. 408,0. 541,0. i57,0. 337,0. 338,0. 166）. The equation between W - SCC （x） and CD4 cell count （y） was y = 120. 913x ＋ 90. 339. Conclusion There is a strong correlation between CD4 T lymphocyte count and lymphocyte count in AIDS patients without antiviral treatment. It can be used as an important indicator of immune status in patients with AIDS. At the same time, we should strengthen the propaganda of AIDS prevention, promote AIDS early detection, early treatment, and improve the quality of life of AIDS patients.

关 键 词：获得性免疫缺陷综合征 CD4^+T淋巴细胞 淋巴细胞计数 晚发现比例 相关性 

分 类 号：R512.91[医药卫生—内科学]