ADRB2基因多态性与支气管哮喘的研究进展  

Research progress between β2-adrenergic receptor gene polymorphisms and bronchial asthma

作　　者：代思思 邱志新[1] 李为民[1] Dai Sisi;QiuZhixin;Li Weimin(Department of Pulmonary and Critical Care,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院呼吸与危重症医学科,成都610041

出　　处：《国际呼吸杂志》2018年第19期1495-1498,共4页International Journal of Respiration

摘　　要：支气管哮喘（简称哮喘）是一种具有异质性的气道慢性炎症性疾病。哮喘患者在哮喘药物的治疗中也表现出明显的异质性。编码β2肾上腺素能受体的ADRB2基因突变可以影响哮喘的易感性、表型和疗效，本文就ADRB2基因多态性与哮喘的研究进展进行综述。Bronchial asthma （asthma） is a heterogeneous chronic inflammatory airway disease. Asthmatic patients also showed significant heterogeneity in the treatment. The ADRB2 gene encoding beta 2 adrenergic receptor mutations are associated with the asthmatic susceptibility, phenotype and response to medication. This article reviewed the research progress between the ADRB2 gene polymorphisms and asthma.

关 键 词：支气管哮喘 ADRB2 Β2肾上腺素能受体 基因多态性 

分 类 号：R562.25[医药卫生—呼吸系统]