抗癫痫药物在妊娠期癫痫患者中的应用分析  

Analysis of antiepileptic drugs application in pregnant women with epilepsy

作　　者：单浩杰 郑东琳 杨帆 周祖彬[1] 苗志娟 宋庆如 李彭举 郑研艳 SHAN Hao-jie;ZHENG Dong-lin;YANG Fan;ZHOU Zu-bin;MIAO Zhi-juan;SONG Qing-ru;LI Peng-ju;ZHENG Yan-yan(Department of Orthopaedic,Shanghai Jiao Tong University Affiliated Sixth People＇s Hospital,Shanghai 200233,China;Huaihe Clinical College,Henan University,Henan Kaifeng 475000,China;Department of Neurology,Huaihe Hospital,Henan University,Henan Kaifeng 475000,China;First Clinical College,Henan University,Henan Kaifeng 475000,China)

机构地区：[1]上海交通大学附属第六人民医院骨科,上海200233 [2]河南大学淮河临床学院,河南开封475000 [3]河南大学淮河医院神经内科,河南开封475000 [4]河南大学第一临床学院,河南开封475000

出　　处：《中国医刊》2018年第10期1131-1135,共5页Chinese Journal of Medicine

基　　金：2016年度河南省科技攻关计划(国际科技合作项目)(162102410015);国家自然科学基金(81472110)

摘　　要：目的探讨妊娠期癫痫患者的抗癫痫药物应用现状。方法收集2009年12月至2016年5月河南大学淮河医院收治的112例妊娠期癫痫患者的临床资料,回顾性分析其抗癫痫药物的使用情况。结果 112例患者中,70例(62.50%)采用单药治疗,其中23例(32.86%)使用丙戊酸钠,15例(21.43%)使用卡马西平,9例(12.86%)使用拉莫三嗪。22例(19.64%)采用两药联合治疗,其中7例(31.82%)使用丙戊酸钠+拉莫三嗪,7例(31.82%)使用丙戊酸钠+卡马西平。7例(6.25%)使用≥3种药物治疗。5例(4.47%)采用其他药物治疗。8例(7.14%)未用药治疗。坚持长期用药者54例(48.22%),间断用药者50例(44.64%)。结论妊娠期癫痫患者主要采用单药治疗,其次为两药联合治疗。传统抗癫痫药物在妊娠期间应用比例仍较大,不规范用药的现象依然多见。Objective To explore the status of antiepileptic drugs（AEDs） application in pregnant women with epilepsy. Method The clinical data of 112 cases of pregnant women with epilepsy who were admitted to Henan University Huaihe Hospital were collected. Retrospective analysis was carried out for the use of antiepileptic drugs in them. Result Among 112 patients, monotherapy were used in 70 cases（62.50%）, including 23 cases（32.86%） with valproate, 15 cases（21.43%） with carbamazepine, 9 cases（12.86%） with lamotrigine. 22 cases（19.64%） were used the therapy of two drugs combination,including 7 cases（31.82%） with valproate ＋ lamotrigine, 7 cases（31.82%） with valproate ＋ carbamazepine. 7 cases（6.25%） were treated by more than 3 drugs. 5 cases（4.47%） were treated by other drugs.8 cases（7.14%） were not treated by any drug. 54 cases（48.22%） adhered to long-term medication. 50 cases（44.64%） took medication only intermittently. Conclusion Pregnant women with epilepsy mainly adopts monotherapy, followed by the therapy of two drugs combination. Traditional antiepileptic drugs were still widely used,and the phenomenon of non-standard drug use were still common.

关 键 词：抗癫痫药物 妊娠期 癫痫 

分 类 号：R971.6[医药卫生—药品]