microRNA-129生物学功能的研究进展  

Research progress in biological function of microRNA-129

作　　者：王玉涵 江小霞[1] WANG Yu-han;JIANG Xiao-xia(Institute of Military Cognition and Brain Sciences,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100085,China;Tibet Vocational Technical College,Lhasa 850032,China)

机构地区：[1]军事科学院军事医学研究院军事认知与脑科学研究所,北京100850 [2]西藏职业技术学院,拉萨850032

出　　处：《军事医学》2018年第5期384-388,共5页Military Medical Sciences

基　　金：国家自然科学基金资助项目(81771998);北京市自然科学基金资助项目(7162142)

摘　　要：微小RNA(microRNA,miRNA,miR)是一类具有20~24个核苷酸长度的非编码单链RNA,在基因表达的转录后调节中发挥重要作用。microRNA-129(miR-129)对肿瘤细胞的抑制作用已经大量研究证实,其重要性不言而喻。该文从细胞增殖、细胞凋亡、侵袭迁移和免疫反应等方面对miR-129在生物进程中的生物学功能,以及其参与调控的信号通路进行综述。同时,还总结了miR-129在炎症反应、血管再生和神经发育中的作用。miR-129的生物学作用虽仍需进一步深入研究和探讨,但其具有巨大的生物功能价值且对于生物进程研究和临床医学治疗意义重大。MicroRNAs （miRNAs） are a class of short non-coding, 20 -24 nucleotides length single-stranded RNAs that play an important role in the regulation of gene expression at post-transcription. It has been extensively confirmed that microRNA-129（ miR-129 ） is the inhibiting factor of tumor cells, and a growing number of studies have recognized its importance. In this review, we summarize the roles of miR-129 in the cellular biological process and the relevant signaling pathways, including cell proliferation, cell cycle, cell apoptosis, invasion migration and immune response. Also, we summarize the roles of miR-129 in inflammation, vascular regeneration and neurogenesis. Although the biological role of miR-129 still needs to be further studied and explored, the potential great biological function of miR-129 is of great significance for biological process research and clinical medical treatment.

关 键 词：microRNA-129 生物学功能 基因调控 

分 类 号：Q522[生物学—生物化学]